Publications by authors named "JinHong Min"

Background: The demand for orthodontic treatment using clear aligners has been gradually increasing because of their superior esthetics compared with conventional fixed orthodontic therapy. This study aimed to evaluate and compare the compressive strength of three-dimensional direct printing aligners (3DPA) with that of conventional thermo-forming aligners (TFA) to determine their clinical applicability. In the experimental group, the 3DPA material TC-85 (TC-85 full) was used to create angular protrusions called rectangular pressure areas (RPA).

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The ability to measure current and voltage is core to both fundamental study and engineering of electrochemical systems, including batteries for energy storage. Electrochemical measurements have traditionally been conducted on macroscopic electrodes on the order of 1 cm or larger. In this Perspective, we review recent developments in using microscopic electrodes (<100 μm) for the study of battery materials.

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This study assessed the accuracy and reliability of artificial intelligence (AI)-reconstructed images of two-dimensional (2D) lateral cephalometric analyses of facial computed tomography (CT) images, which is widely used for the diagnosis of craniofacial deformities and in the planning of their treatment. Facial CT datasets from 40 patients were collected. Original 1 mm slices were reformatted to 3 mm, and then an AI algorithm reconstructed the 3 mm slices and converted them back to 1 mm to generate lateral cephalometric images.

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The effect of W and WO electrodes on the ferroelectric characteristics of HZO (Zr-doped HfO)-based MFM (metal-ferroelectric-metal) capacitors was investigated. During the deposition of tungsten, the W electrode was formed using only Ar gas, while the WO electrode was formed using a mixture of Ar and O gases. The W-based MFM capacitors exhibited superior remnant polarization (2P of 107.

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Thioflavin-T (THT) is a common and indispensable tool for the study of amyloid pathologies and protein aggregation, both in vitro and for histological samples. In this study we expand the use of THT beyond its canonical usage for staining amyloid plaques and demonstrate its novel use as an easy and rapid stain comparable to fluorescent Nissl staining, allowing for clear discernment of neuronal cell bodies and also nucleoli in fixed tissue and live cells. We believe that this is of value for any lab that studies central nervous system (CNS) tissues.

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Article Synopsis
  • Microbes have been linked to Alzheimer's disease since 1908, but the focus has largely been on the amyloid hypothesis, with recent evidence suggesting a common origin involving microbial interactions with key molecules like Aβ, Tau, and ApoE.
  • These molecules, while performing normal functions in neurons, also exhibit antimicrobial properties that can be activated during times of infection, leading to changes in neuron behavior.
  • The emerging "microbial Alzheimer's disease (MAD)" theory posits that long-term microbial infections can lead to neurodegeneration by disrupting crucial copper-based systems involved in neurotransmission and iron balance, pointing towards new potential treatments that target microbial exposure.
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  • The pathophysiology of ALS shows a disruption in copper balance, with signs of both copper deficiency and toxicity, impacting various physiological functions crucial for cell health.
  • Key proteins linked to ALS, like TDP-43 and SOD1, are affected by copper's role in protein stability, leading to harmful aggregation that perpetuates copper imbalance and further cellular damage.
  • Environmental factors such as toxins and heavy metals may exacerbate these issues, suggesting that restoring copper balance alongside neuroprotective treatments could be a promising strategy for ALS management.
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  • Neurodegenerative diseases often involve oxidative stress, inflammation, and protein misfolding, with copper and zinc being particularly impactful in these processes.
  • The tripeptide glycyl-l-histidyl-l-lysine (GHK) can bind to copper, reduce its harmful effects, and prevent cell death caused by copper and zinc in laboratory settings.
  • GHK shows promise as a protective compound that can improve protein solubility and prevent aggregation, suggesting its potential use in treating neurodegenerative diseases related to metal toxicity.
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In this work, the endurance characteristics of Al-doped HfO(HAO)-based metal-ferroelectric-metal (MFM) capacitors (which were annealed at 1000 °C) with various doping concentrations were investigated. The doping concentration was optimized for the high annealing temperature (1000 °C) process. To investigate the impact of cycling pulses on the endurance characteristics of HAO-based MFM capacitor, the rise/fall time () and hold time () for the cycling pulses were varied.

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In this work, the impact of fluorine (CF) and oxygen (O) plasma passivation on HfZrO (HZO) based ferroelectric capacitor was investigated. By the fluorine passivation, the surface trap density and oxygen vacancies in the HZO-based Metal-ferroelectric-insulator-semiconductor (MFIS) capacitors were suppressed, resulting in the increased pristine remnant polarization (2P). The pristine value (2P) of baseline samples annealed at 500 °C and 600 °C were 11.

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The endurance characteristic of Zr-doped HfO (HZO)-based metal-ferroelectric-metal (MFM) capacitors fabricated under various deposition/annealing temperatures in the atomic layer deposition (ALD) process was investigated. The chamber temperature in the ALD process was set to 120 °C, 200 °C, or 250 °C, and the annealing temperature was set to 400 °C, 500 °C, 600 °C, or 700 °C. For the given annealing temperature of 700 °C, the remnant polarization (2P) was 17.

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Article Synopsis
  • Targeting microglia, a type of myeloid cell, is crucial for treating neuroinflammatory diseases like multiple sclerosis (MS), and researchers are exploring topoisomerase 1 (TOP1) inhibitors as potential therapies.
  • Studies show that inhibiting TOP1 with drugs like camptothecin (CPT) and topotecan (TPT) reduces inflammation in microglia and helps alleviate neuroinflammation in living organisms.
  • An innovative nanosystem, MyloGami, designed to specifically deliver TPT to myeloid cells, significantly decreases inflammation and slows the progression of MS, suggesting that TOP1 inhibition in these cells could be a viable treatment strategy for neuroinflammatory disorders.
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We aimed to investigate intracranial pressure (ICP) changes over time and the neurologic prognosis for out-of-hospital cardiac arrest (OHCA) survivors who received targeted temperature management (TTM). ICP was measured immediately after return of spontaneous circulation (ROSC) (day 1), then at 24 h (day 2), 48 h (day 3), and 72 h (day 4), through connecting a lumbar drain catheter to a manometer or a LiquoGuard machine. Neurological outcomes were determined at 3 months after ROSC, and a poor neurological outcome was defined as Cerebral Performance Category 3-5.

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: The coronavirus infection 2019 (COVID-19) pandemic has affected emergency department (ED) management. Its viral transmission necessitates the use of isolation rooms and personal protective equipment for treating suspected patients, such as those with fever. This delays the time until the first encounter with the patients, thereby increasing the length of stay (LOS) in the ED.

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Pattern recognition receptors (PRRs) are crucial for responses to infections and tissue damage; however, their role in autoimmunity is less clear. Herein we demonstrate that 2 C-type lectin receptors (CLRs) Mcl and Mincle play an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Congenic rats expressing lower levels of Mcl and Mincle on myeloid cells exhibited a drastic reduction in EAE incidence.

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Aim: Cerebrospinal fluid (CSF) neuron-specific enolase (NSE) levels increase ahead of serum NSE levels in patients with severe brain injury. We examined the prognostic performance between CSF NSE and serum NSE levels in out-of-cardiac arrest (OHCA) survivors who had undergone target temperature management (TTM).

Methods: This single-centre prospective observational study included OHCA patients who had undergone TTM.

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Introduction: This report describes changes in blood and urine concentrations of glyphosate potassium over time and their correlations with clinical symptoms in a patient with acute glyphosate potassium poisoning.

Case Report: A 67-year-old man visited the emergency center after ingesting 250 mL of a glyphosate potassium-based herbicide 5 h before. He was alert but presented with nausea, vomiting, and bradyarrhythmia with atrial fibrillation (tall T waves).

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Aim: The optimal time to measure serum albumin concentration (SAC) to predict prognosis in cardiac arrest (CA) survivors has not been elucidated. We aimed to compare the relationships between time-related SAC, optic nerve sheath diameter (ONSD), intracranial pressure (ICP), and neurological prognosis in CA survivors.

Methods: We undertook a retrospective study examining CA patients treated with target temperature management (TTM).

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In this study, using the melt-adsorption method, we developed sustained-release microparticles containing the potent drug, tamsulosin HCl, for use as orally disintegrating tablets. A high-speed kneading granulator was used, enabling temperature modulation and uniform material distribution. A lipid and ethylcellulose suspension (Surelease®) was applied to retard drug release, and magnesium aluminometasilicate (Neusilin®) was used as adsorbent.

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Among 80 types of yeast isolated from wild flowers in Daejeon, Korea, two species that have not yet been identified by phylogenetic analysis of the internal transcribed spacer-2 (ITS2) genes and 26S rDNA sequences were identified as Candida sp. 44-C-1 and Cryptococcus sp. 9-D-1.

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We measured physiological functionalities, including antihypertensive angiotensin I-converting enzyme inhibitory activity and immun-stimulating β-glucan content for sixty kinds of Makgeolli that is commercially available from the market. As a result, we selected R-12 commercial raw Makgeolli, with a high content of immuno-stimulating β-glucan, and R-14 commercial raw Makgeolli, exhibiting high antihypertensive activity. Due to the similarities in their overall physicochemical properties and raw materials used for fermentation, we compared the microbial flora in order to investigate the reason for the differences in their functionalities.

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Alachlor and butachlor are commonly used chloroacetanilide herbicides. They are cytotoxic, but there have been rare reported cases of alachlor or butachlor induced erythema multiforme major. We report the case of a 38-year-old farmer with erythema multiforme major due to the occupational exposure to alachlor/butachlor.

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Background: We have previously reported that TNF-α levels correlate to total mycobacterial burden in tuberculosis (TB) patients.

Objective: To characterize the dynamics of cytokine responses in TB patients during chemotherapy to identify potential surrogate markers for effective treatment.

Methods: Following induction by culture filtrate proteins in whole blood, production patterns of TNF-α, IL-10, IFN-γ and IL-12 were measured in 23 non-multidrug-resistant (MDR)-TB and 16 MDR-TB patients and in 31 healthy controls.

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We evaluated the utility of the "QuantiFERON-TB Gold In-Tube" (QuantiFERON) test that uses tuberculosis (TB)-specific antigens for the diagnosis of latent infection in such individuals. We also examined the correlation between the interferon (IFN)-gamma response to these antigens and the exposure risk to TB by evaluating antigen-specific IFN-gamma release in comparison with IFN-gamma release in response to purified protein derivative (PPD) in 3 groups: medical students, nurses in a TB hospital, and TB patients. All nurses and TB patients responded to PPD, whereas 52% (P < 0.

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