Publications by authors named "JinHee Park"

Objective: To examine the correlations between individual characteristics among clients with stroke within public vocational rehabilitation (VR) and the employment outcome, as well as the utilization of VR services and their employment outcomes after VR services.

Design: Observational cohort study SETTING: Nationwide vocational rehabilitation data from the Rehabilitation Service Administration Case Service Report (RSA-911) for fiscal year 2022.

Participants: Individuals with stroke as primary cause of disability MAIN OUTCOME MEASURES: employment status and VR service types RESULTS: Of those with stroke who received VR services (n = 1,793), 653 (36.

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  • The aggregation of α-synuclein in the nervous system leads to α-synucleinopathies, with Lewy body dementia (LBD) being a primary form of dementia characterized by Lewy bodies and neurites.
  • Despite being the second leading cause of dementia after Alzheimer's, there is limited understanding of LBD’s pathological mechanisms and diagnostic criteria.
  • The study used mass spectrometry to identify 179 proteins with significant changes post α-synuclein injection, linking several neurodegenerative pathways and suggesting a potential framework for distinguishing LBD from other dementias based on later cortical proteome changes.
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  • Erlotinib, an EGFR inhibitor approved for lung cancer, may also impact Alzheimer's disease by targeting amyloid β interactions.
  • In experiments with mouse models for AD, erlotinib treatment improved cognitive function, reduced tau phosphorylation and aggregation, and decreased astrogliosis.
  • Overall, erlotinib showed potential as a therapeutic agent for Alzheimer's by enhancing memory and reducing pathological features in the brain.
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Background: Food allergy (FA) affects around 5.6 million children in the United States, conferring risk for negative impacts on growth and psychosocial functioning. While evidence suggests a higher prevalence of feeding difficulties in children with FA, the link between FA and feeding dysfunction remains unclear.

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Aim: This scoping review aims to assess the utility of ultrasound as a prospective tool in measuring body composition and nutritional status in the paediatric population. We provide a comprehensive summary of the existing literature, identify gaps, and propose future research directions.

Methods: We conducted a systematic scoping review following the PRISMA Extension for Scoping Reviews guidelines.

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Aim: Present a study protocol investigating the biobehavioral efficacy of side-lying vs. supine positions on physiologic and behavioural responses of preterm infants during their transition from tube to full oral feeding, and identify associated infant characteristics.

Design: Within-subject cross-over design.

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  • Felodipine, an L-type calcium channel blocker, was previously shown to reduce neuroinflammation in microglial cells and mice, but its effects on tau pathology in Alzheimer's disease were unknown.
  • In the study, felodipine was found to decrease tau pathology-induced microglial activation and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease but did not affect astrogliosis.
  • The findings suggest that felodipine may be a promising therapeutic option for reducing tau hyper-phosphorylation and neuroinflammatory responses in Alzheimer's disease.
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Background: Infants with developmental risk factors are more likely to have feeding problems and develop chronic feeding disorders. Early detection and understanding of the progression of problematic feeding and its relationship with a child's biological functioning and the family feeding environment will enhance effective symptom management and development of interventions to prevent pediatric feeding disorders.

Objectives: The New Through Two (NewThru2) feeding study protocol is described.

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Purpose: To identify symptom clusters among breast cancer survivors and investigate differences in health-related quality of life (HRQoL) and distress based on these discerned symptom clusters using latent profile analysis.

Methods: We enrolled 655 adult breast cancer survivors aged 19 years and older, registered with the Cancer Survivor Integrated Supportive Center from May 2020 to July 2022. The study measured five symptoms-pain, fatigue, insomnia, anxiety, and depression-using a Visual Analogue Scale ranging from 0 to 10 points.

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Purpose: This methodological study evaluated the psychometric properties of the Self-Care of Coronary Heart Disease Inventory version 3 (SC-CHDI v3) in a Korean context.

Methods: The SC-CHDI v3 was translated into Korean following a rigorous translation process. Participants were 452 patients who had experienced coronary heart disease (CHD), all recruited from a tertiary hospital in Korea.

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  • Breast cancer is the most frequently diagnosed cancer in women globally, causing significant distress related to diagnosis and treatment among patients.
  • A study surveyed 641 breast cancer survivors to measure distress levels and identify influential factors using machine learning techniques, revealing that 57.7% experienced severe distress.
  • Key factors impacting distress included depression, relationship issues, work/school stress, fatigue, and emotional concerns like fear and nervousness, demonstrating the effectiveness of machine learning in identifying vulnerable patients for better support in clinical settings.
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Given the growing concern over the deployment of toxic chemicals in warfare, the rapid and accurate removal and detection of cyanogen chloride (CK) as a blood agent has become increasingly critical. However, conventional physisorbents and chemisorbents used in military respirators are insufficient for the effective removal of CK. In this study, we demonstrate the chemisorption and sensing abilities of Co(m-DOBDC) (m-DOBDC = 4,6-dioxo-1,3-benzenedicarboxylate) for CK via electrophilic aromatic substitution (EAS) in humid environments.

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This study investigated the effects of far-infrared (FIR) irradiation on low-density lipoprotein cholesterol (LDL-C) uptake by human hepatocellular carcinoma G2 (HepG2) cells via the regulation of proprotein convertase subtilisin/kexin type 9 (PCSK9). FIR irradiation for 30 min significantly decreased PCSK9 expression (p < 0.01) in HepG2 cells.

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Non-invasive diagnostics are crucial for the timely detection of renal cell carcinoma (RCC), significantly improving survival rates. Despite advancements, specific lipid markers for RCC remain unidentified. We aimed to discover and validate potent plasma markers and their association with dietary fats.

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  • Dopamine is crucial for cognitive functions and inflammation, linking it to neurodegenerative diseases like Alzheimer's disease (AD).
  • L-DOPA treatment in 5xFAD mice (an AD model) reduced neuroinflammation and decreased Aβ plaques by increasing specific enzyme levels.
  • However, L-DOPA did not affect tau hyperphosphorylation or tau kinase levels, indicating its limitations in influencing tau pathology in this context.
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Acidimicrobium sp. strain A6 is a recently discovered autotrophic bacterium that is capable of oxidizing ammonium while reducing ferric iron and is relatively common in acidic iron-rich soils. The genome of Acidimicrobium sp.

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  • - The study developed a new diagnostic test to quickly and accurately detect cerebrospinal fluid (CSF) leaks after spinal surgery, focusing on measuring transferrin (TF) levels in CSF and serum.
  • - It utilized a "hook effect" that occurs when TF levels are excessively high to distinguish between CSF and serum samples, tested on 37 patients and compared to a reference standard.
  • - The new LFI sensor showed exceptional results, achieving 100% sensitivity and specificity for detecting CSF leaks, which could greatly improve patient care and recovery post-surgery.
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Self-assembly-based structural transition has been explored for various applications, including molecular machines, sensors, and drug delivery. In this study, we developed new redox-active metal-organic frameworks (MOFs) called DGIST-10 series that comprise π-acidic 1,4,5,8-naphthalenediimide (NDI)-based ligands and Ni ions, aiming to boost ligand-self-assembly-driven structural transition and study the involved mechanism. Notably, during the synthesis of the MOFs, a single-crystal-amorphous-single-crystal structural transition occurred within the MOFs upon radical formation, which was ascribed to the fact that radicals prefer spin-pairing or through-space electron delocalization by π-orbital overlap.

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  • - A new one-dimensional coordination polymer, 1D-DGIST-18, has been designed to be structurally flexible, allowing it to transition into a three-dimensional network via interactions with solvents and ligands.
  • - The choice of solvents for exchange prior to drying affects the structural characteristics of 1D-DGIST-18, leading to the formation of varying levels of porosity (micro, meso, and macro).
  • - Immersing 1D-DGIST-18 in acetone results in 'turn-on' fluorescence due to the formation of excimers, with structural changes detailed through single-crystal X-ray diffraction, paving the way for future materials with customizable properties.
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Purpose: This study explored the work adjustment trajectory and its predictors and characteristics among newly registered nurses.

Methods: A total of 245 newly registered nurses working in a university hospital provided general baseline characteristics and completed a work adjustment questionnaire along with self-report measures of clinical competency, psychological capital, preceptor exchange, social support, and role conflict when they started working independently (baseline) and at 7 and 12 months after employment. Data were collected from July 2020 to August 2022.

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Skeletal muscles are important for body movement, postural maintenance, and energy metabolism. Muscle atrophy is caused by various factors, including lack of exercise, age, genetics, and malnutrition, leading to the loss of muscle mass. The / signaling pathway plays a key role in the regulation of muscle protein synthesis and degradation.

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Metal-organic cages (MOCs) have garnered significant attention due to their unique discrete structures, intrinsic porosity, designability, and tailorability. However, weak inter-cage interactions, such as van der Waals forces and hydrogen bonding can cause solid-state MOCs to lose structural integrity during desolvation, leading to the loss of porosity. In this work, a novel strategy to retain the permanent porosity of Cu-paddlewheel-based MOCs, enabling their use as heterogeneous catalysts is presented.

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Cross-responsive chemical sensors are in high demand owing to their ability to distinguish a broad range of analytes. In this study, a vapochromic sensor array based on metal-organic frameworks (MOFs), which exhibits distinct patterns when exposed to volatile organic compounds (VOCs) and humidity, is developed. Conventional sensor arrays consist of various receptors that produce different responses.

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Unsaponifiable matter (USM) from wheat bran, a by-product obtained from wheat milling, is abundant in health-promoting compounds such as phytosterols, tocopherols, policosanols, and alkylresorcinols. This study aimed to examine the effects of USM from the wheat bran of normal and waxy type wheat, Saekeumkang (SKK) and Shinmichal (SMC), on hepatic lipid accumulation in free fatty acid (FFA)-induced hepatocytes and to investigate the cellular mechanism. The total phytochemical contents were 46.

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Background: With the recent global mpox outbreak, the JYNNEOS vaccine (Modified Vaccinia Ankara-Bavarian Nordic) was developed as a third-generation smallpox vaccine and initially favored for mpox immunization. Vaccine-associated side effects contribute to vaccine hesitancy. Consequently, tracking adverse events post-immunization is crucial for safety management.

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