Insight into migration of Cr(VI) in self-hardening slurry materials for trench cutoff wall.

The migration and immobilization of heavy metals in soil and groundwater pose significant environmental challenges, particularly in the context of Cr(VI), a highly toxic and mobile contaminant. Self-hardening slurry materials, commonly used for trench cutoff walls, have gained great attention due to their potential for pollutant containment. However, the relationship between their adsorption properties and pollutant diffusion behaviors remains poorly understood.

Luminescent Metal-Organic Framework with Outstanding "Turn-On" Hg Sensing Ability First Constructed by an AIE Ligand.

Hg is highly toxic and can cause serious harm to the environment and humans. Thus, it is vital to develop efficient Hg sensors. In this work, a LMOF-based (LMOF = luminescent metal-organic framework) "turn-on" Hg sensor () is first developed by an aggregation-induced emission (AIE) functional ligand.

The epitranscriptional factor PCIF1 orchestrates CD8 T cell ferroptosis and activation to control antitumor immunity.

T cell-based immunotherapies have revolutionized cancer treatment, yet durable responses remain elusive. Here we show that PCIF1, an RNA N 2'-O-dimethyladenosine (mA) methyltransferase, negatively regulates CD8 T cell antitumor responses. Whole-body or T cell-specific Pcif1 knockout (KO) reduced tumor growth in mice.

One-sided device-independent random number generation through fiber channels.

Randomness is an essential resource and plays important roles in various applications ranging from cryptography to simulation of complex systems. Certified randomness from quantum process is ensured to have the element of privacy but usually relies on the device's behavior. To certify randomness without the characterization for device, it is crucial to realize the one-sided device-independent random number generation based on quantum steering, which guarantees security of randomness and relaxes the demands of one party's device.

RB functions as a key regulator of senescence and tumor suppression.

The Retinoblastoma (RB) protein is crucial for regulating gene transcription and chromatin remodeling, impacting cell cycle progression, cellular senescence, and tumorigenesis. Cellular senescence, characterized by irreversible growth arrest and phenotypic alterations, serves as a vital barrier against tumor progression and age-related diseases. RB is crucial in mediating senescence and tumor suppression by modulating the RB-E2F pathway and cross talking with other key senescence effectors such as p53 and p16.

5-methylcytosine methylation of MALAT1 promotes resistance to sorafenib in hepatocellular carcinoma through ELAVL1/SLC7A11-mediated ferroptosis.

Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) play a crucial role in sorafenib resistance in hepatocellular carcinoma (HCC), and lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a dysregulated lncRNA in sorafenib-resistant HCC cells. However, the underlying regulatory mechanisms of MALAT1 in sorafenib-resistant HCC cells remain unclear. In the present study, we demonstrated that 5-methylcytosine (mC) methylation catalyzed by NSUN2 and ALYREF contributed to the RNA stability and upregulation of MALAT1.

Pyridyl/Pyrimidyl-Containing Ligands Modulating Two Cd(II)-MOFs with Distinct Architectures and Al Sensing Abilities.

It is a challenging task to develop metal-organic frameworks (MOFs) with fascinating architectures and outstanding performance. In this work, two novel Cd(II)-MOFs, [Cd()(BDC)·1.5-PrOH] () and [Cd()(BDC)(HO)] (), with distinct sensing performances are successfully synthesized by pyridyl/pyrimidyl-containing functional ligands 9,10-bis(di(pyridine-4-yl)methylene)-9,10-dihydroanthracene () and 9,10-bis(di(pyrimidin-5-yl)methylene)-9,10-dihydroanthracene ().

LincROR promotes tumor growth of colorectal cancer through the miR-145/WNT2B/WNT10A/Wnt/β-catenin regulatory axis.

Colorectal cancer (CRC) is a prevalent form of malignant tumor, and the current clinical treatments are far from satisfactory. Identifying new therapeutic targets is therefore essential for clinical practices. The long intergenic non-protein coding RNA lincROR has been shown to play a significant role in the tumorigenesis of various cancers.

mutation and familial pediatric acute lymphoblastic leukemia: A case report.

Hereditary factors contribute to the pathogenesis of pediatric leukemia. However, few studies have reported gene mutation pathopoeias. This paper reports genetic mutations associated with hereditary acute lymphoblastic leukemia.

Cairo pentagon tessellated covalent organic frameworks with mcm topology for near-infrared phototherapy.

Despite the prevalent of hexagonal, tetragonal, and triangular pore structures in two-dimensional covalent organic frameworks (2D COFs), the pentagonal pores remain conspicuously absent. We herein present the Cairo pentagonal tessellated COFs, achieved through precisely chosen geometry and metrics of the linkers, resulting in unprecedented mcm topology. In each pentagonal structure, porphyrin units create four uniform sides around 15.

Three-Dimensional Covalent Organic Frameworks Based on Linear and Trigonal Linkers for High-Performance HO Photosynthesis.

The design of three-dimensional covalent organic frameworks (3D COFs) using linear and trigonal linkers remains challenging due to the difficulty in achieving a specific non-planar spatial arrangement with low-connectivity building units. Here, we report the novel 3D COFs with linear and trigonal linkers, termed TMB-COFs, exhibiting srs topology. The steric hindrance provides an additional force to alter the torsion angles of peripheral triangular units, guiding the linear unit to connect with the trigonal unit into 3D srs frameworks, rather than the more commonly observed two-dimensional (2D) hcb structures.

Unraveling the mechanism of flower color variation in by integrated metabolome and transcriptome analyses.

is one of the most important oil crops in the world. Breeding oilseed rape with colorful flowers can greatly enhance the ornamental value of and thus improve the economic benefits of planting. As water-soluble flavonoid secondary metabolites, anthocyanins are very important for the synthesis and accumulation of pigments in the petals of plants, giving them a wide range of bright colors.

Photosensitizing metal covalent organic framework with fast charge transfer dynamics for efficient CO photoreduction.

Designing artificial photocatalysts for CO reduction is challenging, mainly due to the intrinsic difficulty of making multiple functional units cooperate efficiently. Herein, three-dimensional metal covalent organic frameworks (3D MCOFs) were employed as an innovative platform to integrate a strong Ru(ii) light-harvesting unit, an active Re(i) catalytic center, and an efficient charge separation configuration for photocatalysis. The photosensitive moiety was precisely stabilized into the covalent skeleton by using a rational-designed Ru(ii) complex as one of the building units, while the Re(i) center was linked a shared bridging ligand with an Ru(ii) center, opening an effective pathway for their electronic interaction.

Panchromatic Light-Harvesting Three-Dimensional Metal Covalent Organic Frameworks for Boosting Photocatalysis.

Constructing artificial photocatalysts with panchromatic solar energy utilization remains an appealing challenge. Herein, two complementary photosensitizers, [Ru(bpy)] (bpy = 2,2'-bipyridine) and porphyrin dyes, have been cosensitized in metal covalent organic frameworks (MCOFs), resulting in the MCOFs with strong light absorption covering the full visible spectrum. Under panchromatic light irradiation, the cosensitized MCOFs exhibited remarkable photocatalytic H evolution with an optimum rate of up to 33.

Two AIE-Ligand-Based 2-D Luminescent Metal-Organic Frameworks as Fe Sensors.

The design and synthesis of high-performance sensors are very important but remain great challenges. In this work, a new aggregation-induced-emission (AIE) molecule 4,4'-(((9-fluoren-9-ylidene)methylene)bis(4,1-phenylene))dipyridine () was successfully synthesized and first developed as a functional ligand to construct two isomorphic metal-organic frameworks (MOFs) [M()(OBBA)] [M = Cd (), Co (); HOBBA = 4,4'-oxybisbenzoic acid]. They adopt [M(COO)] flywheel clusters, OBBA bridges, and terminal ligands as building units to form isomorphic 2-D networks with Lewis base active cites (uncoordinated pyridyl N).

Aucubin Promotes Osteogenic Differentiation and Facilitates Bone Formation through the lncRNA-H19 Driven Wnt/-Catenin Signaling Regulatory Axis.

Objectives: Traditional Chinese medicine has been used to treat bone fracture for hundreds of years, which exerts a significant improvement in fracture healing. Aucubin, a derivative isolated from , has been demonstrated to possess anti-inflammatory, immunoregulatory, and antioxidative potential. In the present study, our aim was to explore its function in bone regeneration and elucidate the underlying mechanism.

USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy.

Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological and pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion of (ubiquitin-specific protease 8) in intestinal epithelial cells (IECs) leads to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied by increased IEC death and signs of lipid peroxidation.

Role of co‑inhibitory molecules in the treatment of psoriasis (Review).

Psoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in the pathogenesis of psoriasis.

The Mediating Role of Family Functions Between Pregnancy-Related Anxiety and Sleep Quality: A Cross-Sectional Study.

Objective: To examine the relationship between pregnancy-related anxiety, family functions, and sleep quality, and to determine whether family functions mediate the relationship between pregnancy-related anxiety and sleep quality.

Methods: A cross-sectional survey was conducted on pregnant women between April to August in 2022 in the obstetrics outpatient clinic of a tertiary care hospital in the Ningxia Hui Autonomous Region of China. A total of 1014 pregnant women aged 18 years and older were surveyed.

EIF4A3-negatively driven circular RNA β-catenin (circβ-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.

Background: Circβ-catenin, our first reported circRNA, has been reported to mediate tumorigenesis in various cancers. However, its biological functions and underlying mechanisms in colorectal cancer (CRC) remain unknown.

Methods: The qRT-PCR examination was used to detect the expression of circβ-catenin, miR-197-3p, and CTNND1 in cells and human tissues.

PD-1 regulation in immune homeostasis and immunotherapy.

Harnessing the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis is pivotal in autoimmunity and cancer immunotherapy. PD-1 receptors on immune cells engage with one of its ligands, PD-L1 or PD-L2, expressed on antigen-presenting cells or tumor cells, driving T-cell dysfunction and tumor immune escape. Thus, targeting PD-1/PD-L1 revitalizes cytotoxic T cells for cancer elimination.