Identification and validation of autophagy-related genes in Hirschsprung's disease.

Background: Hirschsprung's disease (HSCR) is a congenital disorder characterized by aganglionosis in the intermuscular and submucosal nerve plexuses of the gut, leading to impaired gastrointestinal function. Although the precise cause and pathophysiology of HSCR remain elusive, increasing evidence points to a significant role of autophagy in its development, warranting further investigation into its underlying mechanisms.

Methods: This study utilized publicly available microarray expression profiling datasets, GSE96854 and GSE98502, from the Gene Expression Omnibus (GEO).

Ileocecal valve-preservation ileocecostomy (IVPI) in infants with extremely short distal ileum after primary stoma.

Purpose: Preserving the ileocecal valve (ICV) has shown significant benefits. We present our experience with 18 infants who underwent ileocecal valve-preservation ileocecostomy (IVPI) with an extremely short distal ileum after primary ileostomy.

Methods: A retrospective analysis was conducted on IVPI cases between 2014 and 2020.

Rapunzel syndrome in children: a retrospective review of ten cases combined with literature review in a tertiary referral center.

Purpose: Rapunzel syndrome is an uncommon condition in children, and its clinical features remain unclear. This study presents the largest single-center series of pediatric cases to date, with the objective of documenting the clinical characteristics and treatment approaches for children with Rapunzel syndrome.

Methods: A retrospective study was conducted in children with Rapunzel syndrome from 2019 to 2023.

Personal Exposure to Source-Specific Particulate Polycyclic Aromatic Hydrocarbons and Systemic Inflammation: A Cross-Sectional Study of Urban-Dwelling Older Adults in China.

Environmental exposure to ambient polycyclic aromatic hydrocarbons (PAHs) can disturb the immune response. However, the evidence on adverse health effects caused by exposure to PAHs emitted from specific sources among different vulnerable subpopulations is limited. In this cross-sectional study, we aimed to evaluate whether exposure to source-specific PAHs could increase systemic inflammation in older adults.

Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis.

Background: Necrotizing enterocolitis (NEC) is the most common severe gastrointestinal emergency in neonates. We designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of neonates.

Methods: Using the 16S ribosomal DNA (rDNA) sequencing method, we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates: patients undergoing jejunostomy to treat NEC (NP group), neonates undergoing jejunostomy to treat other conditions (NN group), and neonates with NEC undergoing conservative treatment (NC group).

The role of preserved bowel and mesentery fixation in apple-peel intestinal atresia.

Objective: This study explored the feasibility of mesoplasty with end-to-side anastomosis in the treatment of different apple-peel mesenteric defects with high jejunal atresia.

Methods: A retrospective analysis was performed on 42 premature infants admitted to the hospital between 2014 and 2021. Prenatal ultrasound scans revealed bowel dilatation.

Analysis of Factors Influencing Outcomes in Preterm Infants With Necrotizing Enterocolitis.

Background: To explore the surgical outcomes between patients with perforated and non-perforated neonatal necrotizing enterocolitis (NEC) and identify indications for surgical intervention.

Methods: The surgical outcomes of 271 children with NEC admitted to the Seventh Medical Center of Chinese PLA General Hospital between August 2009 and August 2020 were retrospectively analyzed. The patients were divided into the non-perforated and perforated groups.

Characteristics, Source Contributions, and Source-Specific Health Risks of PM-Bound Polycyclic Aromatic Hydrocarbons for Senior Citizens during the Heating Season in Tianjin, China.

Polycyclic aromatic hydrocarbons (PAHs) have carcinogenic impacts on human health. However, limited studies are available on the characteristics, sources, and source-specific health risks of PM2.5-bound PAHs based on personal exposure data, and comparisons of the contributions of indoor and outdoor sources are also lacking.

Associations of Exposure to Fine Particulate Matter Mass and Constituents with Systemic Inflammation: A Cross-Sectional Study of Urban Older Adults in China.

Systemic inflammation is a key mechanism in the development of cardiovascular diseases induced by exposure to fine particles (particles with aerodynamic diameter ≤2.5 μm [PM]). However, little is known about the effects of chemical constituents of PM on systemic inflammation.

Fine particle-bound PAHs derivatives at mountain background site (Mount Tai) of the North China: Concentration, source diagnosis and health risk assessment.

Ten nitrated polycyclic aromatic hydrocarbons (nPAHs) and 4 oxygenated polycyclic aromatic hydrocarbons (oPAHs) in fine particulate matter (PM) samples from Mount Tai were analyzed during summer (June to August), 2015. During the observation campaign, the mean concentration of total nPAHs and oPAHs was 31.62 pg/m and 0.

[Reconstruction of forefoot skin defect with island flap pedicled with lateral tarsal artery].

Objective: To investigate the therapeutic effect of island flap pedicled with lateral tarsal artery for forefoot skin defect.

Methods: From March 2007 to January 2009, 12 cases with forefoot skin defects were treated by reversed island flap pedicled with lateral tarsal artery.

Results: All the flaps survived completely with a followed-up period of 8-22 months, 13 months in average.

[Application of AO miniplate and screw in the treatment of metacarpophalangeal joint periarticular fractures].

Objective: To evaluate the clinical efficacies for open reduction and internal fixation of unstable periarticular fractures of metacarpophalangeal joint (MCP) with the AO miniature plate system.

Methods: A total of 265 patients (172 males and 93 females) with 302 MCP periarticular fractures were retrospectively reviewed. Their mean age was 32.

[Effects of decimeter wave and sodium hyaluronate product on postoperative adhesions in flexor tendon].

Objective: To compare the effect of decimeter wave with sodium hyaluronate product (SHP) on preventing and treating peritendinous adhesion and promoting tendon healing.

Methods: Totally 96 healthy male white 6-month-old Leghorn chickens weighing (2.24 +/- 0.

[Clinical application of groin skin and iliac bone composite graft in contracture of first web space and reconstruction of pollicis opponens function].

Objective: To investigate the therapeutic effects of the groin skin and iliac bone composite graft on the repair of severe contracture of the first web space and one-stage reconstruction of the pollicis opponens function under the condition of no ideal muscle or tendon used.

Methods: From July 2003 to February 2006, 5 patients (4 males, 1 females; age range, 20-38 years) with severe contracture of the first web space with loss of the pollicis opponens function were treated by the groin skin and iliac bone composite graft, with the clinical observation performed. The defect was caused by a crush injury in 3 patients, by an explosion injury in 1 patient, and by a wrist joint mutilation injury in 1 patient.

[A probe to the treatment of Madelung deformity].

Objective: To explore a method of treating Madelung deformity.

Methods: Seven cases of Madelung deformity had been treated with the excision of ulnar carpi ulnaris segment and distal osteotomy of radius and tight constrict of extensor carpi ulnaris from Mar. 2000 to Nov.