Publications by authors named "Jin-zhu Yin"
Article Synopsis
- The study investigates how gestational weight gain (GWG) affects the timing of lactogenesis II (DOL II), which is when mammals start producing mature breast milk after giving birth.
- It analyzes data from 16 articles, encompassing over 248,000 women, finding that excessive GWG increases the risk of delayed lactogenesis II, especially in overweight, obese, and underweight women who gained too much weight.
- Additionally, women with excessive GWG are likely to stop exclusive breastfeeding within one month after giving birth, indicating a negative impact of high GWG on breastfeeding practices.
This study aims to investigate whether tetramethylpyrazine(TMP) can stimulate angiogenesis in cerebral microvascular endothelial cells and alleviate cerebral ischemic stroke(CIS) and to explore the underlying mechanisms. In the animal study, adult Sprague-Dawley rats(n=15) were assigned into sham surgery(sham), middle cerebral artery occlusion/reperfusion(MCAO/R), and MCAO/R+TMP(intraperitoneal injection of 20 mg·kg~(-1)) groups. The neurological function was evaluated by the Z-Longa method.
View Article and Find Full Text PDFNon-coding RNAs are key players and promising therapeutic targets in atherosclerosis.
Front Cell Dev Biol
September 2023
Cardiovascular disease (CVD) is the primary cause of death in humans. Atherosclerosis (AS) is the most common CVD and a major cause of many CVD-related fatalities. AS has numerous risk factors and complex pathogenesis, and while it has long been a research focus, most mechanisms underlying its progression remain unknown.
View Article and Find Full Text PDFArticle Synopsis
- Multiple sclerosis (MS) is a complicated central nervous system disease characterized by demyelination and inflammation.
- Hydroxyfasudil, a metabolite of Fasudil, has shown promise in alleviating symptoms and pathological damage in an animal model of MS (EAE), while also reducing immune cell infiltration.
- The treatment led to a favorable shift in T cell balance, promoted anti-inflammatory responses, and suggested protective effects on the blood-brain barrier, indicating its potential as a new therapy for MS.
[Role of ubiquitin ligase Ring2 in DNA damage induced by benzo[a]pyrene].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
June 2013
Objective: To investigate the role of ubiquitin ligase Ring2 in the DNA damage induced by benzo[a]pyrene (B[a]P).
Methods: The expression of Ring2 in human bronchial epithelial (16HBE) cells was inhibited by small interfering RNA (siRNA) to obtain siRNA-Ring2 16HBE cells. The siRNA-Ring2 16HBE cells, as well as normal 16HBE cells, were exposed to B[a]P (0, 1, 2, 4, 8, 16, and 32 µmol/L) for 24 h; other siRNA-Ring2 16HBE cells and normal 16HBE cells were exposed to B [a]P (16 µmol/L) for 0, 1, 2, 4, 8, 12, and 24 h.
[Clinical significance of protein Z alteration in patients with cardio-cerebral thrombotic diseases].
Zhonghua Xue Ye Xue Za Zhi
November 2004
Article Synopsis
- The study aimed to investigate how protein Z (PZ) levels change in patients with cardio-cerebral thrombotic diseases and their relationship with factor X (FX) levels.
- Results showed that PZ levels were significantly lower in patients with acute ischemic stroke (AIS) and acute myocardial infarction (AMI) compared to healthy individuals, while FX levels were elevated in these patient groups.
- The decrease in PZ was linked to the severity and recurrence of the diseases, with age also playing a role in PZ levels, but no significant correlation was found with gender.