Bone loss in patients with spinal cord injury: Incidence and influencing factors.

Purpose: To investigate the incidence and influencing factors of bone loss in patients with spinal cord injury (SCI).

Methods: A retrospective case-control study was conducted. Patients with SCI in our hospital from January 2019 to March 2023 were collected.

Hip subluxation in children with spinal cord injury: Incidence and influencing factors.

Hip subluxation is a common complication in children with spinal cord injury. This study aimed to investigate the incidence and influencing factors of hip subluxation and discuss prevention strategies. Medical records of children with spinal cord injury were reviewed.

Clinical characteristics of pediatric traumatic spinal cord injury in China: A single center retrospective study.

Objective: To investigate the clinical characteristics of children with traumatic spinal cord injury (SCI) admitted to a research rehabilitation center between 2011 and 2020, with a view to generate crucial data for understanding and prevention of pediatric traumatic SCI.

Design: Retrospective cohort study.

Setting: The National Rehabilitation Research Center of China, Beijing, China.

Prognosis of traumatic spinal cord injury in children: Follow-up of 86 patients.

Purpose: The long-term situation of children with spinal cord injury (SCI) was investigated, and suggestions for helping them better return to the society were provided.

Methods: SCI patients less than 18 years old hospitalized in Beijing Boai Hospital from January 2011 to December 2020 were retrospectively analyzed. Information including motor function, complications, characteristic changes, self-care abilities, school attendance and social participation were collected by telephone interview and electronic questionnaire.

Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury.

Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS.

Ischemic damage may play an important role in spinal cord injury during dancing.

Study Design: Retrospective analysis.

Setting: China Rehabilitation Research Center, Beijing, China.

Objective: To explore possible mechanisms underlying spinal cord injury (SCI) in children caused by hyperextension of the spine while dancing.

Heterogeneity among traumatic spinal cord injuries at the thoracolumbar junction: helping select patients for clinical trials.

Study Design: Retrospective analysis.

Setting: China Rehabilitation Research Center, Beijing, China.

Objective: A retrospective study that documents the modalities and clarifies the heterogeneity among spinal cord injuries (SCIs) caused by trauma to the thoracolumbar vertebral junction.

[Transferrin receptor imaging for tracing mesenchymal stem cells implanted in the spinal cord].

Objective: To explore the feasibility of tracing mesenchymal stem cells in vivo with scintigraphy.

Methods: Transferrin receptor expression of cultured mesenchymal stem cells (hMSCs) was quantified with radioligand-receptor binding assay before the cells were transplanted into the spinal cord of rabbits. (131)I-labeled transferrin was then administered into the subarachnoid space of the rabbits, and scintigraphic images were acquired with a gamma camera at different time points after the administration.

[D2 receptor expression on immortalized human neural progenitor cell line hNPC-TERT in vitro and in vivo].

Objective: To observe D(2) receptor expression on human neural progenitor cell line hNPC-TERT before and after transplantation into rabbit central nervous system.

Methods: D(2) receptor expression on cultured hNPC-TERT cells was verified and quantitatively analyzed with immunofluorescence assay and receptor radio ligand binding assay, respectively. 3 x 10(6) hNPC-TERT cells were implanted in the spinal cord of New Zealand rabbit with HeLa cells as the control.

[Tracking neural progenitor cells transplanted into rabbit spinal cord by detection of dopamine receptor 2 with positron emission computed tomography].

Objective: To explore the effect of in vivo positron emission computed tomography (PET) in tracking the stem cells transplanted into spinal cord.

Methods: Telomerase-immortalized human neural progenitor cells of the line hNPC-TERT were cultured. HeLa cells were used as control cells.

Effect of human neural progenitor cells on injured spinal cord.

Objective: To study whether human neural progenitor cells can differentiate into neural cells in vivo and improve the recovery of injured spinal cord in rats.

Methods: Human neural progenitor cells were transplanted into the injured spinal cord and the functional recovery of the rats with spinal cord contusion injury was evaluated with Basso-Beattie-Bresnahan (BBB) locomotor scale and motor evoked potentials. Additionally, the differentiation of human neural progenitor cells was shown by immunocytochemistry.

[In vitro study of combination rhOPG-Fc and alendronate on inhibition osteoclast].

Objective: To study the effect of combination rhOPG-Fc and alendronate on mature osteoclasts.

Methods: Recombinant human osteoprotegerin secretory expression in P. pastoris was performed.

[Transferrin receptor expression of human mesenchymal stem cells and in vitro tracking by autoradiography after transplantation in spinal cord].

Objective: To determine transferrin receptor (TfR) expression of human mesenchymal stem cells (MSCs) in vitro and after transplantation in rabbit spinal cord,and to detect implanted MSCs by in vitro autoradiography.

Methods: Human mesenchymal stem cells (hMSCs) were isolated from fetal blood. Flow cytometry assay, immuno-fluorescent staining and receptor binding assay were used to determine TfR expression of hMSCs.