Radiomics for differentiating tumor deposits from lymph node metastasis in rectal cancer.

Background: Tumor deposits (TDs) are not equivalent to lymph node (LN) metastasis (LNM) but have become independent adverse prognostic factors in patients with rectal cancer (RC). Although preoperatively differentiating TDs and LNMs is helpful in designing individualized treatment strategies and achieving improved prognoses, it is a challenging task.

Aim: To establish a computed tomography (CT)-based radiomics model for preoperatively differentiating TDs from LNM in patients with RC.

Radiomics for predicting perineural invasion status in rectal cancer.

Background: Perineural invasion (PNI), as a key pathological feature of tumor spread, has emerged as an independent prognostic factor in patients with rectal cancer (RC). The preoperative stratification of RC patients according to PNI status is beneficial for individualized treatment and improved prognosis. However, the preoperative evaluation of PNI status is still challenging.

Shaft Function of Kinesin-1's α4 Helix in the Processive Movement.

Introduction: Kinesin-1 motor is a molecular walking machine constructed with amino acids. The understanding of how those structural elements play their mechanical roles is the key to the understanding of kinesin-1 mechanism.

Methods: Using molecular dynamics simulations, we investigate the role of a helix structure, α4 (also called switch-II helix), of kinesin-1's motor domain in its processive movement along microtubule.

Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2/HO-1 signaling pathway.

Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl-induced acute liver injury, especially its effect on the Nrf2/HO-1 signaling pathway.

The positive clinical therapeutically effects of Escin on advanced thyroid cancer.

The incidences of thyroid cancer keep rising worldwide over the past few decades. Although most thyroid cancers are indolent and highly curable, the treatment for advanced thyroid cancer remains challengeable in clinical practice. We performed two separate cohorts to evaluate the safety and efficiency of Escin in patients with advanced thyroid cancer .

[Swallowing and laryngeal function preserving in surgical treatment of the head and neck tumors involving the tongue root].

Objective: To investigate the surgical technique which could preserve the swallowing and laryngeal function effectively in the malignant head and neck tumors involving the tongue root.

Methods: From January 2003 to December 2008, 31 cases of malignant head and neck tumors involving the tongue base had been treated in this hospital were retrospectively analyzed. There were 27 males and 4 females in which 9 cases of primary malignant tumor were from the base of tongue; 3 cases were from the tonsil, 11 cases were from supraglottic laryngeal carcinoma and 8 cases were from hypopharyngeal carcinoma.

[Effects of central corneal thickness and corneal curvature on measurement of intraocular pressure with Goldmann applanation tonometer and non-contact tonometer].

Objective: To investigate the effects of central corneal thickness (CCT) and corneal curvature (CC) on intraocular pressure (IOP) measurements by the Goldmann applanation tonometer (GAT) and the non-contact tonometer (NCT).

Methods: One hundred and twenty patients were recruited from the clinic of Peking Union Medical College Hospital. The CCT was measured by ultrasound pachymetry and the mean radius of CC by using Canon PK-5 refractometer.

[Analysis of the effectiveness of laser in situ keratomileusis two years after surgery].

Objective: To evaluate the effectiveness of laser in situ keratomileusis (LASIK) for myopia after 2 year follow-up.

Methods: LASIK surgery was performed for 95 eyes (49 cases) with refractive dioptres (from -1.00 to -16.

[Static and dynamic contrast sensitivity of myopic eyes before and after laser in situ keratomileusis].

Objective: To evaluate the static and dynamic contrast sensitivity changes in myopic patients before and after laser in situ keratomileusis (LASIK).

Methods: Seventy-three eyes in 37 patients with myopia (with or without astigmatism) who received LASIK were tested for static and dynamic contrast sensitivities using the METRO VISION MON ELEC I system at 0.7, 1.