Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells.

Four novel bifluorescent Zn(II)-cryptolepine-cyclen complexes, namely [Zn(BQTC)]Cl (Zn(BQTC)), [Zn(BQA) (Cur)Cl] (Zn(BQACur)), [Zn (TC)]Cl (Zn(TC)), and [Zn (AP) (Cur)Cl] (Zn(APCur)), bearing curcumin (H-Cur), cyclen (TC), 1,10-phenanthrolin-5-amine (AP), and novel cryptolepine-cyclen derivatives (BQTC and BQA) were prepared for cell nucleus- and mitochondria-specific imaging. MTT assay results indicated that Zn(BQTC) and Zn(BQACur) exhibit stronger anticancer activity against cisplatin-resistant A549R lung tumor cells than ZnCl, Zn(TC), Zn(APCur), H-Cur, TC, AP, BQTC, and BQA. Due to the dual fluorescence characteristic of Zn(BQTC), selective fluorescence imaging of the nucleus and mitochondria of A549R cancer cells was conducted.

A new class of nickel(II) oxyquinoline-bipyridine complexes as potent anticancer agents induces apoptosis and autophagy in A549/DDP tumor cells through mitophagy pathways.

A new class of nickel(II) oxyquinoline-bipyridine complexes, namely, [Ni(La1)(Lb6)] (Ni1), [Ni(La1)(Lb2)] ·CHOH (Ni2), [Ni(La7)(Lb11)]·2HO (Ni3), [Ni(La1)(Lb9)] (Ni4), [Ni(La1)(Lb8)] (Ni5), [Ni(La2)(Lb1)] (Ni6), [Ni(La2)(Lb6)]·CHOH (Ni7), [Ni(La2)(Lb11)]·CHOH (Ni8), [Ni(La2)(Lb3)] (Ni9), [Ni(La2)(Lb2)]·CHOH (Ni10), [Ni(La2)(Lb5)]·CHOH (Ni11), [Ni(La2)(Lb7)] (Ni12), [Ni(La3)(Lb2)] (Ni13), [Ni(La4)(Lb4)]·2CHOH (Ni14), [Ni(La4)(Lb8)]·2.5CHOH (Ni15), [Ni(La4)(Lb11)]·1.5CHOH (Ni16), [Ni(La5)(Lb7)] (Ni17), [Ni(La5)(Lb10)]·CHOH (Ni18), [Ni(La6)(Lb11)]·3CHOH (Ni19), [Ni(La7)(Lb7)]·2CHOH (Ni20), [Ni(La7)(Lb8)]·2CHOH (Ni21) and [Ni(La7)(Lb1)]·2CHOH (Ni22) bearing oxyquinoline (H-La1-H-La7) and bipyridine derivatives (Lb1-Lb11) were synthesized and characterized by elemental analysis, X-ray crystallography, infrared (IR) spectroscopy and electrospray mass spectrometry (ESI-MS).

[Studies on terpenoids from Zygophyllum fabago].

This study was to investigate the chemical constituents of the aerial part of Zygophyllumfabago, by phytochemical methods. The compounds were isolated by silica gel and Sephadex LH-20 column chromatographies from the EtOAc extract. Their structures were characterized by various spectroscopic data (1H-NMR, 13C-NMR, MS) and comparison with the literature.

A novel linkage to generalized vitiligo on 4q13-q21 identified in a genomewide linkage analysis of Chinese families.

Generalized vitiligo is a common, autoimmune, familial-clustering depigmentary disorder of the skin and hair that results from selective destruction of melanocytes. Generalized vitiligo is likely a heterogeneous disease, with five susceptibility loci reported so far--on chromosomes 1p31, 6p21, 7q, 8p, and 17p13--in white populations. To investigate vitiligo susceptibility loci in the Chinese population, we performed a genomewide linkage analysis in 57 multiplex Chinese families, each with at least two affected siblings, and we identified interesting linkage evidence on 1p36, 4q13-q21, 6p21-p22, 6q24-q25, 14q12-q13, and 22q12.