Cinnamaldehyde and Doxorubicin Co-Loaded Graphene Oxide Wrapped Mesoporous Silica Nanoparticles for Enhanced MCF-7 Cell Apoptosis.

Background: Combined chemotherapy is often affected by the different physicochemical properties of chemotherapeutic drugs, which should be improved by the reasonable design of co-loaded preparations.

Purpose: A kind of simple but practical graphene oxide (GO) wrapped mesoporous silica nanoparticles (MSN) modified with hyaluronic acid (MSN@GO-HA) were developed for the co-delivery of cinnamaldehyde (CA) and doxorubicin (DOX), in order to enhance their combined treatment on tumor cells and reduce their application defects.

Methods: The MSN@GO-HA was constructed by MSN (loading CA via physical diffusion) and GO-HA (modified with HA and loading DOX via π-π stacking) through the electrostatic adsorption, followed by the physicochemical characterization, serum stability and in vitro release study.

Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4.

Two new compounds, triacremoniate (1) and dietziamide C (2) along with known compounds β-Adenosine (3) and acrepyrone A (4) were obtained from the mangrove-derived fungus Acremonium citrinum. MMF4. Their structures were unambiguously determined by extensive spectroscopic methods, including UV, IR, HRESIMS and NMR.

Enantioselective Direct α-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis.

The first catalytic asymmetric α-arylation of pyrazol-5-ones has been established by using 2-indolylmethanols as direct electrophilic arylation reagents under the cooperative catalysis of Pd(0) and a chiral phosphoric acid, which afforded the α-arylation products of pyrazol-5-ones in generally high yields and good enantioselectivities (up to 99% yield, >99% ee).

Propagation of SH waves in an infinite/semi-infinite piezoelectric/piezomagnetic periodically layered structure.

In this paper, SH bulk/surface waves propagating in the corresponding infinite/semi-infinite piezoelectric (PE)/piezomagnetic (PM) and PM/PE periodically layered composites are investigated by two methods, the stiffness matrix method and the transfer matrix method. For a semi-infinite PE/PM or PM/PE medium, the free surface is parallel to the layer interface. Both PE and PM materials are assumed to be transversely isotropic solids.

TLR2 Plays a Critical Role in HMGB1-Induced Glomeruli Cell Proliferation Through the FoxO1 Signaling Pathway in Lupus Nephritis.

The objective of this study was to examine the role and possible mechanisms of toll-like receptor 2 (TLR2) in high-mobility group box chromosomal protein 1 (HMGB1)-induced mouse mesangial cell (MMC) proliferation and glomeruli proliferation of MRL/Fas(lpr) mice. First, the expression of proliferating cell nuclear antigen (PCNA), TLR2 and Forkhead box protein O1 (FoxO1) messenger RNA (mRNA) and protein in the glomeruli of MRL/Fas(lpr) mice was quantified, and the correlation with cell proliferation of glomeruli was analyzed. Then, lipopolysaccharide (LPS), TLR2 neutralization antibody, and small hairpin TLR2 (shTLR2) were used to confirm the role of TLR2 in HMGB1-induced MMC proliferation.

Interface energy effect on the dispersion relation of nano-sized cylindrical piezoelectric/piezomagnetic composites.

Interface between the constituents plays an important role in the non-destructive detection of smart piezoelectric/piezomagnetic devices. The propagation of SH waves in nano-sized cylindrically multiferroic composites consisting of a piezoelectric layer and a piezomagnetic central cylinder is investigated, and the size-dependent dispersion relation with interface effect is derived. The general solutions of decoupled governing equation in different regions are expressed by using Bessel functions, and the unknown coefficients are determined by satisfying the boundary conditions at the inner interface with negligible thickness and the outer surface of the structure.

SH wave propagation in magnetic-electric periodically layered plates.

In this paper, dispersive behavior and band structure of SH waves in magnetic-electric (ME) periodically layered plate are investigated by the transfer matrix method. Two kinds of unit cell form, one is piezoelectric (PE)/piezomagnetic (PM)/PE, and the other is PM/PE/PM, are considered in detailed. A peculiar case of the generalized single-celled plate is first presented and then the multi-celled periodical layered plates for discussion on the propagation behaviors and the band characteristics of SH waves, respectively.

Fundamental formulations and recent achievements in piezoelectric nano-structures: a review.

Piezoelectric nano-structures have been regarded as the next-generation piezoelectric material due to their inherent nano-sized piezoelectricity. This review summarizes the recent theoretical and experimental findings in piezoelectric nano-structures, including piezoelectric nanowires, nanoplates, nanobeams, nanofilms, nanoparticles, and piezoelectric heterogeneous materials containing piezoelectric nano-inhomogeneities. To begin, the types of piezoelectric nano-structured materials and the wide application of piezoelectric nano-structures in recent years are delineated.