The accuracy of DNA methylation detection in endometrial cancer screening: A systematic review and meta-analysis.

Objective: DNA methylation is the hallmark of early endometrial cancer and can be detected through non-invasive methods. The present study systematically reviewed the efficacy of DNA methylation detection for endometrial cancer screening through exfoliative cytology.

Methods: A systematic literature review was performed through the following databases from inception to October 7, 2024: PubMed, Embase, and the Cochrane Library.

Comparison of MACT and 5Fu+ACT-D chemotherapy regimens in the treatment of low-risk gestational trophoblastic neoplasia.

The study aimed to compare the efficacy of methotrexate (MTX) cervical injections + actinomycin-D (ACT-D)(MACT) and 5-fluorouracil (5-Fu) + actinomycin-D (5-Fu plus ACT-D) chemotherapy regimens for low-risk gestational trophoblastic neoplasia (LR-GTN). Clinical data from 66 LR-GTN patients, admitted to the Beijing Obstetrics and Gynecology Hospital from January 2010 to April 2012, were analysed retrospectively. In total, 32 patients were treated with a MACT therapeutic regimen and the remaining 34 with a 5Fu + ACT-D therapeutic regimen.

Interleukin-6-induced epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in human cervical carcinoma.

Epithelial-mesenchymal transition (EMT) is an important process in the invasion and metastasis of human cervical carcinoma. The pro-inflammatory cytokine interleukin-6 (IL-6) has been shown as an EMT inducer in multiple carcinomas. However, whether the EMT program can be induced by IL-6 and the mechanisms underlying the IL-6-induced EMT in human cervical carcinoma remain to be determined.

High-risk endometrial cancer may be benefit from adjuvant radiotherapy plus chemotherapy.

Objective: To present patterns of practice and outcomes in the adjuvant treatment of intermediate- and high-risk endometrial cancer.

Methods: Retrospective data on 224 women with intermediate-risk and high-risk endometrial cancer from 1999 to 2006 were reviewed. All patients underwent surgical staging.

[Mechanistic study of radiosensitization by gemcitabine on human squamous carcinoma cell line of the cervix].

Objective: To investigate whether gemcitabine (dFdC) at the non-cytotoxic concentration enhances the effect of irradiation on human squamous carcinoma cells of the uterine cervix (HeLa) in vitro, and to evaluate the mechanism by which dFdC at the non-cytotoxic concentration [24 h 10% inhibiting concentration (IC(10))] is able to enhance radiation-induced cytotoxicity to HeLa in vitro.

Methods: The non-cytotoxic concentration (24 h IC(10)) of dFdC was determined by methyl thiazolyl tetrazolium (MTT). After exposure to the non-cytotoxic concentration (0.