Selective solid-phase extraction of artificial chemicals from milk samples using multiple-template surface molecularly imprinted polymers.

A novel multiple-template surface molecularly imprinted polymer (MTMIP) was synthesized using ofloxacin and 17β-estradiol as templates and modified monodispersed poly(glycidylmethacrylate-co-ethylene dimethacrylate) (PGMA/EDMA ) beads as the support material. Static adsorption, solid-phase extraction and high-performance liquid chromatography were performed to investigate the adsorption properties and selective recognition characteristics of the polymer templates and their structural analogs. The maximum binding capacities of ofloxacin and 17β-estradiol on the MTMIP were 9.