Vaccarin alleviates septic cardiomyopathy by potentiating NLRP3 palmitoylation and inactivation.

Background: Sepsis often leads to significant morbidity and mortality due to severe myocardial injury. As is known, the activation of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome crucially contributes to septic cardiomyopathy (SCM) by facilitating the secretion of interleukin (IL)-1β and IL-18. The removal of palmitoyl groups from NLRP3 is a crucial step in the activation of the NLRP3 inflammasome.

Tobramycin-resistant small colony variant mutant of serovar Typhimurium shows collateral sensitivity to nitrofurantoin.

The increasing antibiotic resistance poses a significant global health challenge, threatening our ability to combat infectious diseases. The phenomenon of collateral sensitivity, whereby resistance to one antibiotic is accompanied by increased sensitivity to another, offers potential avenues for novel therapeutic interventions against infections unresponsive to classical treatments. In this study, we elucidate the emergence of tobramycin (TOB)-resistant small colony variants (SCVs) due to mutations in the gene, which render .

Spontaneous rotational symmetry breaking in KTaO heterointerface superconductors.

Broken symmetries play a fundamental role in superconductivity and influence many of its properties in a profound way. Understanding these symmetry breaking states is essential to elucidate the various exotic quantum behaviors in non-trivial superconductors. Here, we report an experimental observation of spontaneous rotational symmetry breaking of superconductivity at the heterointerface of amorphous (a)-YAlO/KTaO(111) with a superconducting transition temperature of 1.

[Experimental research on characteristics of temperature field distribution of mild moxibustion and sparrow-pecking moxibustion].

Objective: To explore the temperature field distribution and variation rules during treatment with mild moxibustion and sparrow-pecking moxibustion of TCM.

Methods: Six healthy subjects were selected. Mild moxibustion and sparrow-pecking moxibustion were exerted at Zusanli (ST 36) respectively, for 25 min.

Effects of ozone water irrigation and spraying on physiological characteristics and gene expression of tomato seedlings.

Tomato seedlings were used as experimental materials and treated with 1.0, 2.0, 3.

Experimental detection of a Majorana mode in the core of a magnetic vortex inside a topological insulator-superconductor Bi(2)Te(3)/NbSe(2) heterostructure.

Majorana fermions have been intensively studied in recent years for their importance to both fundamental science and potential applications in topological quantum computing. They are predicted to exist in a vortex core of superconducting topological insulators. However, it is extremely difficult to distinguish them experimentally from other quasiparticle states for the tiny energy difference between Majorana fermions and these states, which is beyond the energy resolution of most available techniques.

Protective effect of metformin on myocardial injury in metabolic syndrome patients following percutaneous coronary intervention.

Objectives: The present study tested the hypothesis that pretreatment with metformin decreases postprocedural myocardial injury and improves clinical outcomes in metabolic syndrome patients following percutaneous coronary intervention (PCI).

Methods: We enrolled 152 metabolic syndrome patients with no prior history of metformin treatment. Patients scheduled for elective coronary intervention were randomized to the metformin or control group 7 days before the procedure.

Spatial and energy distribution of topological edge states in single Bi(111) bilayer.

By combining scanning tunneling microscopy and spectroscopy, angle-resolved photoemission spectroscopy, and density functional theory band calculations, we directly observe and resolve the one-dimensional edge states of single bilayer (BL) Bi(111) islands on clean Bi(2)Te(3) and Bi(111)-covered Bi(2)Te(3) substrates. The edge states are localized in the vicinity of step edges having an ∼2  nm wide spatial distribution in real space and reside in the energy gap of the Bi(111) BL. Our results demonstrate the existence of nontrivial topological edge states of single Bi(111) bilayer as a two-dimensional topological insulator.

The coexistence of superconductivity and topological order in the Bi₂Se₃ thin films.

Three-dimensional topological insulators (TIs) are characterized by their nontrivial surface states, in which electrons have their spin locked at a right angle to their momentum under the protection of time-reversal symmetry. The topologically ordered phase in TIs does not break any symmetry. The interplay between topological order and symmetry breaking, such as that observed in superconductivity, can lead to new quantum phenomena and devices.

[Coupling analysis of agro-ecolomic system in gully area of Loess Plateau in 1949-2008: a case study in Changwu County of Shaanxi Province].

Based on the analysis of the coercing and dynamic evolution relationships between agro-economic system and agro-ecological system, and by using modified entropy method, the weight of each evaluation index for the agro-ecolomic system in Changwu County of Shaanxi Province was determined, and, by employing coupling degree model, the coupling processes of agro-ecolomic system in the gullyarea of Loess Plateau were investigated. From 1949 to 2008, the agro-ecolomic system in the County experienced three stages of "traditional extensive agriculture", "agricultural mechanization", and "agricultural pre-modernization". In corresponding to the implement of national macro policies, the coupling degree of the agro-ecolomic system reached two peaks standing for utmost increasing phase and three valleys standing for coordinate development phase.

[In vivo noninvasive detection of vulnerable atherosclerotic plaque by (99)Tc(m)-Annexin V imaging in an atherosclerotic rabbit model.].

Objective: Apoptosis contributes to the instability of the atherosclerotic (AS) lesions. The vulnerable plaque was identified in vivo by detecting the apoptosis with radiolabeled annexin V in an atherosclerotic rabbit model.

Methods: Eight male New Zealand white rabbits on 2% cholesterol diet for 2 weeks had abdominal aortic balloon injury and fed a 2% cholesterol diet for another 15 weeks (AS group), 3 rabbits fed a normal rabbit chow for 17 weeks without balloon injury served as controls.

[Rosiglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice].

Objective: To study the effect of rosiglitazone on atherosclerosis and potential mechanism in ApoE-knockout mice.

Methods: Thirty-two 6-week-old ApoE-knockout mice were used as atherosclerosis model in two groups: rosiglitazone group (n = 18) and control group (n = 14). Each group contained equal numbers of male and female mice.