Publications by authors named "Jin-hua Yi"
[Detection of multiple gene mutations in non-small-cell lung cancer by suspension microarray].
Zhonghua Yi Xue Za Zhi
December 2009
Article Synopsis
- - The study aims to create an advanced microarray for high-speed detection of key gene mutations (p53, p16, Rb, and EGFR) linked to non-small-cell lung cancer (NSCLC) for better molecular diagnosis.
- - Researchers developed specific probes for these mutations, analyzing genomic DNA from cancer and normal lung tissue samples, finding significant mutation rates in NSCLC specimens compared to normal tissues.
- - The new microarray showed high sensitivity (81.5%) and specificity (90%) in detecting mutations, indicating its potential to enhance NSCLC diagnosis and inform targeted therapies.
[Refolding of the fusion protein of recombinant enterokinase light chain rEKL].
Sheng Wu Gong Cheng Xue Bao
September 2006
The fusion protein of enterokinase light chain, DsbA-rEKL, was expressed mainly in inclusion body in E. coli. The recombinant bacteria was fermented to high density, with high expression of the fusion protein.
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