[Analysis of Genomic Landscape in Patients with Acute Myeloid Leukemia].

Objective: To investigate the gene mutation occurved in AML patients with 29 kinds of fusion genes and 51 kinds of tumor gene.

Methods: Next-generation sequencing (NGS) was used to detected the 49 kinds of targeted gene. FLT3 internal tandem duplication (FLT3-ITD), CALR, NPM1 and CEBPA mutation were detected by DNA-based PCR and Sanger sequencing.

Comparative serum proteomic analysis of serum diagnosis proteins of colorectal cancer based on magnetic bead separation and maldi-tof mass spectrometry.

Background: At present, the diagnosis of colorectal cancer (CRC) requires a colorectal biopsy which is an invasive procedure. We undertook this pilot study to develop an alternative method and potential new biomarkers for diagnosis, and validated a set of well-integrated tools called ClinProt to investigate the serum peptidome in CRC patients.

Methods: Fasting blood samples from 67 patients diagnosed with CRC by histological diagnosis, 55 patients diagnosed with colorectal adenoma by biopsy, and 65 healthy volunteers were collected.

5-(2-Meth-oxy-phen-yl)-1,3,4-thia-diazol-2-yl 2-meth-oxy-benzoate hemihydrate.

In the title compound, C(17)H(14)N(2)O(4)S·0.5H(2)O, the mol-ecule, with the exception of the two meth-oxy-phenyl groups, is nearly planar with an r.m.

Ethyl 2-(2-hy-droxy-5-nitro-phen-yl)acetate.

In the crystal structure of the title compound, C(10)H(11)NO(5), inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into chains along the b-axis direction. Weak C-H.·O hydrogen bonds also occur.

[Effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing].

Objective: To observe the effect of optimizing anesthetic injecting sequence during induction on fentanyl-induced coughing.

Methods: One hundred and twenty ASA I or II elective patients undergoing general anesthesia were randomly allocated to optimized group or control group: the optimized group induced with midazolam 0.06 mg/kg, followed by fentanyl 1 mg/kg at 1 min later, vecuronium 0.

Ethyl 5-methyl-imidazo[1,2-a]pyridine-2-carboxyl-ate.

The title compound, C(11)H(12)N(2)O(2), was synthesized from the reaction of 6-methyl-pyridin-2-amine and ethyl 3-bromo-2-oxopropionate. In the mol-ecular structure, the six- and five-membered rings are individually almost planar with r.m.