Protective efficacy of GRA12 or GRA7 recombinant proteins encapsulated in PLGA nanoparticles against acute infection in mice.

Background: Toxoplasma gondii is an apicomplexan parasite that affects the health of humans and livestock, and an effective vaccine is urgently required. Nanoparticles can modulate and improve cellular and humoral immune responses.

Methods: In the current study, poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles were used as a delivery system for the T.

[Distribution of pathogenic bacteria in patients of injuries combined with infection after May 12 Wenchuan Earthquake and drug resistance thereof].

Objective: To investigate the distribution of pathogenic bacteria in the patients of injuries combined with infection after May 12 Wenchuan Earthquake and the drug resistance thereof.

Methods: Bacterial culture and identification were conducted on 139 clinical specimens from 108 patients with open injuries combined with infection. Drug-sensitive test was carried out by Kirby-Bauer method on the isolated strains.

[Transthoracic echocardiography in transcatheter closure of atrial septal aneurysm combined with secoundum-type atrial septal defect].

Objective: To explore the value of transthoracic echocardiography (TTE) in transcatheter closure of atrial septal aneurysm (ASA) combined with secoundum-type atrial septal defect (ASD).

Methods: Fourteen patients (3 males and 11 females) who had ASA combined with secoundum-type ASD were diagnosed by TTE or transesophageal echocardiography. The ASA projected to the right atrium in all patients.

[Short and mid-term effects of percutaneous transcatheter closure of ventricular septal defects on the cardiac remodeling].

Objective: To evaluate the short and mid-term changes of the cardiac morphology after percutaneous transcatheter closure of ventricular septal defects (VSD) with transthoracic echocardiography (TTE).

Methods: The left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left atrial diameter (LAd), and right ventricular diameter (RVd) in 30 VSD patients were measured before the VSD closure,and on the 3rd day, 3rd month, and 6th month after the VSD closure by TTE.

Results: LVEDD and LVEDV significantly decreased on the 3rd day after the VSD closure compared with pre-VSD closure.

[Serum level of homocysteine and the development of collateral circulation in patients with severe coronary artery stenosis].

Objective: To investigate the relationship between serum level of homocysteine and the development of collaterals in patients with severe coronary artery stenosis (SCAS).

Methods: Eighty patients with at least one vessel stenosis over 90% among the 3 main vessels of coronary artery were consecutively enrolled into the study according to angiographic estimation. The development of collaterals was classified by Rentrop's method.

Improving the management of anemia in hemodialysis patients by implementing the continuous quality improvement program.

Background: Anemia is common in hemodialysis patients, and improvement in anemia management is possible with the implementation of continuous quality improvement (CQI) programs. The aim of this study is to improve anemia management in chronic hemodialysis patients using CQI.

Methods: Ninety hemodialysis patients in our single center were enrolled in the study.

[Formation and function of coronary collateral circulation and their influencing factors].

Objective: To clarify the formation and function of coronary collateral circulation (CCC) in coronary artery disease (CAD) patients with severe coronary artery stenosis and their influencing factors.

Methods: Coronary angiography was performed on 266 CAD patients with severe coronary stenosis. CCC formation was evaluated by Rentrop rating on those 266 patients and 401 severe stenosis arteries; while in CCC formed patients, CCC function was evaluated by Werner collateral collection (CC) rating.