Publications by authors named "Jin-Zhen Guo"
Article Synopsis
- The study highlights the significant issue of severe hyperbilirubinemia in infants across different regions of China, noting insufficient exploration of its causes.
- Data from 783 infants revealed that ABO incompatibility, glucose-6-phosphate dehydrogenase deficiency, and intracranial hemorrhage were the main causes, with the central south region showing notably higher bilirubin levels.
- The findings suggest that tailored clinical interventions and improved monitoring strategies are essential, particularly in the central south where unique causes and higher severity are observed.
Rationale: Rectal atresia caused by necrotizing enterocolitis (NEC) is a serious and rare complication in children. Magnetic compression anastomosis (MCA) has been effectively applied in children with congenital oesophageal atresia and biliary atresia. Herein, we reported a case of successfully application of MCA in an infant with rectal atresia following NEC.
View Article and Find Full Text PDFRationale: Neonatal long-gap esophageal atresia (LGEA) with tracheoesophageal fistula (TEF) is an uncommon but serious congenital malformation of the esophagus in newborns, and it remains challenging for pediatric surgeons. Magnetic compress has been shown to be effective for the treatment of LGEA in children and adults. However, the implementation of this unique technique for neonatal LGEA has not been evaluated.
View Article and Find Full Text PDF[A clinical analysis of bacterial meningitis in full-term and preterm infants].
Zhongguo Dang Dai Er Ke Za Zhi
October 2019
Objective: To study the clinical features and prognosis of bacterial meningitis in full-term and preterm infants.
Methods: A retrospective analysis was performed for the clinical data of 102 neonates with bacterial meningitis. According to the gestational age, they were divided into a preterm group (n=46) and a full-term group (n=56).
Objective: To study the efficacy of different preparations of budesonide combined with pulmonary surfactant (PS) in improving blood gas levels and preventing bronchopulmonary dysplasia (BPD) in preterm infants with neonatal respiratory distress syndrome (NRDS).
Methods: A total of 184 preterm infants who developed NRDS within 4 hours after birth were randomly administered with PS + continuous inhalation of budesonide aerosol (continuous aerosol group), PS+budesonide solution (solution group), PS + single inhalation of budesonide aerosol (single aerosol group), and PS alone, with 46 neonates in each group. The changes in arterial blood gas levels, rate of invasive mechanical ventilation after treatment, time of assisted ventilation, rate of repeated use of PS, and the incidence of BPD were compared between the four groups.
[Association between polymorphism of IRF6 rs2235371 locus and nonsyndromic cleft lip with or without cleft palate].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
April 2012
Objective: To assess the association between polymorphism of interferon regulatory factor 6 (IRF6) gene rs2235371 locus and nonsyndromic cleft lip with or without cleft palate in Chinese population.
Methods: Blood samples from 106 patients and their parents and 129 controls and their parents were collected. The polymorphism of IRF6 rs2235371 locus was determined with PCR-restriction fragment length polymorphism (PCR-RFLP) method.
Article Synopsis
- The study aimed to identify genetic factors related to nonsyndromic cleft lip and/or palate (NSCL/P) in Northern Chinese individuals using genetic mapping techniques.
- Researchers collected DNA samples from multiple families and analyzed 382 genetic markers to find links between these markers and NSCL/P.
- Results indicated significant linkages on chromosomes 1 (1q32-q42) and 2 (2p24-p25), with stronger evidence suggesting that specific genes in these regions may interact and influence the risk of developing NSCL/P.
[Relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate].
Beijing Da Xue Xue Bao Yi Xue Ban
August 2009
Objective: To explore the relationship between genetic polymorphisms of MTHFR C677T and nonsyndromic cleft lip with or without palate in Chinese population.
Methods: There were 97 NSCL/P case-parent triads that were selected as case group. At the same period, 104 healthy subjects were selected together with their biological parents as control group.
[No association of the A2756G polymorphism of methionine synthase gene with nonsyndromic cleft lip with or without cleft palate].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
June 2009
Objective: To study the association of the A2756G polymorphism of the methionine synthase (MS) gene with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Chinese.
Methods: Ninety-seven NSCL/P case-parent triads were selected as the case group. One hundred and four healthy subjects and their biological parents were selected as control group.
[Construction and primary analysis of subtractive library induced by soybean mosaic virus (SMV)].
Sheng Wu Gong Cheng Xue Bao
March 2005
Article Synopsis
- SMV is a major soybean disease that significantly impacts yield and quality, and studying resistance genes can improve breeding.
- Researchers created a subtractive cDNA library from the soybean resistance line DongNong 8143 after infecting it with SMV No.1, allowing the identification of specific gene expressions in response to the virus.
- They sequenced 64 clones from the library, found that 38 clones corresponded to known genes, and identified resistance-related functions related to pathogen defense and potential new genes among the remaining clones.