Publications by authors named "Jin-Ye Lu"
Background: Nuciferine (NUC), a natural compound extracted from lotus leaves, has been proven to have anti-obesity effects. However, the development and application of NUC as an anti-obesity drug in dogs are hindered due to its poor water solubility and low bioavailability.
Objective: To promote the development of NUC-related products for anti-obesity in dogs, this study prepared NUC into a liposome formulation and evaluated its characteristics, pharmacokinetics in dogs, and anti-obesity effects on high-fat diet dogs.
Article Synopsis
- Phthalates, harmful chemicals linked to breast cancer, can enter aquatic ecosystems and accumulate in organisms through the food chain, prompting the need for effective detection methods.
- The researchers developed a new fluorescent sensor called BANP, which can detect dibutyl phthalate (DBP) in water with a sensitivity of 0.13 μg/g and has successfully identified DBP in contaminated fish meat.
- BANP not only detects DBP but also monitors its effects on human breast cancer cells, as the release of andrographolide from DBP-treated cells inhibits their growth, highlighting its potential for environmental and health applications.
Gold as a coordinator of an imidazole conjugated dye of BODIPY derivatives for the identification of simple mercaptans.
Spectrochim Acta A Mol Biomol Spectrosc
April 2022
Article Synopsis
- Rapid detection of mercaptans using gold (Au) can enhance material analysis and environmental pollutant monitoring.
- A new water-soluble fluorescent sensor called BIM, based on a BODIPY derivative, was developed, which shows a strong response to Au and significant fluorescence emission when combined.
- The sensor effectively distinguishes between different mercaptans, detecting thioglycolic acid at a limit of 0.014 µM, highlighting the potential for improved fluorescent chemosensors through gold coordination competition.
Article Synopsis
- Drug-resistant bacteria are making it tough to effectively use antimicrobial agents, prompting the need for new treatment technologies.
- Researchers created a photoactivated nanoparticle called BCNBA@ZIF by combining a specific BODIPY compound with a metal-organic framework, which shows structural changes when exposed to light.
- Under blue LED light, BCNBA@ZIF activates to release antibacterial components and produce reactive oxygen species, making it an innovative solution for fighting bacteria while being less toxic to healthy cells.