Association of blood vitamin A with osteoarthritis: a nationally representative cross-sectional study.

Objectives: Vitamin A plays an important role in health, especially regarding its impact on bone tissue. Vitamin A can lead to bone damage and deformity, thus becoming an important causative factor in osteoarthritis. In this study, we aimed to evaluate the association of serum vitamin A with osteoarthritis.

Mo-doped CoP nanoparticles embedded bamboo-like N-doped carbon nanotube modified hollow carbon nanocage for electrochemical sensing of dopamine in human serum and meat samples.

Rapid and sensitive detection of dopamine (DA) concentration in body and food is of great significance for the prevention of neurological diseases. Herein, Mo-doped CoP nanoparticles embedded bamboo-like nitrogen-doped carbon nanotube-modified hollow nanocages are prepared using Mo-ZIF-8@ZIF-67 as a self-sacrificing template. The hollow nanostructures modified by carbon nanotubes provide a large specific surface area and abundant active sites.

Role of Hydrophobic Modification in Spermine-Based Poly(β-amino ester)s for siRNA Delivery and Their Spray-Dried Powders for Inhalation and Improved Storage.

After RNAi was first discovered over 20 years ago, siRNA-based therapeutics are finally becoming reality. However, the delivery of siRNA has remained a challenge. In our previous research, we found that spermine-based poly(β-amino ester)s are very promising for siRNA delivery.

Char and soot records of the Holocene fire history and its implications for climate-vegetation change and human activities within the Guanzhong Basin, southern Loess Plateau, China.

Black carbon in sediments has been widely used as a proxy for biomass burning/fire activity to reconstruct fire history and its evolution. Wildfire studies have revealed that different types of black carbon (char and soot) are formed due to changes in combustion efficiency. In this study, we obtained black carbon and its two subtypes, char and soot, from a typical Holocene aeolian loess-paleosol section in the Chilanqiao Ruins within the Guanzhong Basin, southern Loess Plateau, China.

Postmastectomy radiotherapy in patients with TN breast cancer: a single center experience and a meta-analysis.

Purpose: Postmastectomy radiotherapy (PMRT) in patients with TN breast cancer is still controversial. This study was to evaluate the survival prognosis of TN patients with or without PMRT.

Patients And Methods: From January 2006 to May 2017, 2606 female breast cancer patients underwent mastectomy in our medical center, among whom 402 patients of TN stage with or without PMRT were finally analyzed.

Geniposide ameliorates atherosclerosis by regulating macrophage polarization via perivascular adipocyte-derived CXCL14.

Ethnopharmacological Relevance: Gardenia jasminoides Ellis is a traditional Chinese medicine that has been used for treatment of various diseases, including atherosclerosis by clearing heat and detoxication. Geniposide is considered as the effective compounds responsible for the therapeutic efficacy of Gardenia jasminoides Ellis against atherosclerosis.

Aim Of The Study: To investigate the effect of geniposide on atherosclerosis burden and plaque macrophage polarization, with focus on its potential impact on CXCL14 expression by perivascular adipose tissue (PVAT).

Adjuvant Therapy With PD1/PDL1 Inhibitors for Human Cancers: A Systematic Review and Meta-Analysis.

Background: Immune checkpoint inhibitors (ICIs) have made a breakthrough in the systemic treatment of patients with advanced tumors. However, little is known about their efficacy and safety in adjuvant settings after the resection of solid tumors.

Methods: We performed a meta-analysis on the efficacy and safety of programmed death 1 (PD1)/PD-1 ligand (PDL1) inhibitors in adjuvant therapy after tumor resection using Review Manager 5.

Qualitative and quantitative analysis of ephedrine stimulants in urine by ultra-performance liquid chromatography-tandem mass spectrometry.

Rationale: Ephedrine analogues are stimulants that are explicitly required to be quantified and characterized in the Anti-Doping Prohibited List of the World Anti-Doping Agency. Given the difficulty of distinguishing diastereoisomers, the qualitative and quantitative analyses of ephedrine diastereoisomers are difficult.

Methods: An ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC/MS/MS) method was developed to detect five ephedrine analogues, and two pairs of diastereoisomers were identified using this method.

The Prognostic Value of ctDNA and bTMB on Immune Checkpoint Inhibitors in Human Cancer.

Background: Circulating tumor DNA (ctDNA) levels and blood tumor mutation burden (bTMB) have a significant impact on the prognosis of tumor patients. However, their prognostic role in immune checkpoint inhibitors (ICIs) in cancer patients is still unclear.

Methods: We used the Review Manager software (version 5.

Prognostic Impact of Memory CD8(+) T Cells on Immunotherapy in Human Cancers: A Systematic Review and Meta-Analysis.

Objective: The objective of this systematic review and meta-analysis was to determine the prognostic value of memory CD8(+) T cells in cancer patients with immunotherapy.

Methods: EMBASE, MEDLINE (PubMed), and Web of Science databases were searched to identify suitabile articles published before March 2021. Risk of bias on the study level was assessed using the Cochrane Bias Risk Assessment Tool.

Combination of Immune Checkpoint Inhibitors and Radiotherapy for Advanced Non-Small-Cell Lung Cancer and Prostate Cancer: A Meta-Analysis.

Objectives: Immune checkpoint inhibitors (ICI) combined with radiotherapy (RT) have emerged as a breakthrough therapy in the treatment of various cancers. The combination has a strong rationale, but data on their efficacy and safety are still limited. Hence, we comprehensively searched the database and performed this study to elucidate the clinical manifestations of this combined strategy.

S100A8 promotes epithelial-mesenchymal transition and metastasis under TGF-β/USF2 axis in colorectal cancer.

Background: The transforming growth factor-β (TGF-β) pathway plays a pivotal role in inducing epithelial-mesenchymal transition (EMT), which is a key step in cancer invasion and metastasis. However, the regulatory mechanism of TGF-β in inducing EMT in colorectal cancer (CRC) has not been fully elucidated. In previous studies, it was found that S100A8 may regulate EMT.

3D PBV-Net: An automated prostate MRI data segmentation method.

Prostate cancer is one of the most common deadly diseases in men worldwide, which is seriously affecting people's life and health. Reliable and automated segmentation of the prostate gland in MRI data is exceptionally critical for diagnosis and treatment planning of prostate cancer. Although many automated segmentation methods have emerged, including deep learning based approaches, segmentation performance is still poor due to the large variability of image appearance, anisotropic spatial resolution, and imaging interference.

The Nrf2/PGC1 Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.

Drug resistance remains a barrier in the clinical treatment of ovarian cancer. Proteasomal and antioxidant activities play important roles in tumor drug resistance, and increasing evidence suggests the existence of an interaction between antioxidant and proteasomal activities. However, the mechanism of the synergistic effects of proteasomal activity and antioxidation on tumor drug resistance is not completely clear.

Characterizing the effect of packaging material and storage temperature on the flavor profiles and quality of soy sauce.

The effect of packaging material and storage temperature on two types of soy sauce was investigated. Ethanol content decreased significantly in all tested samples after storage ( < 0.05).

[Regularities of application of acupoints to relieving clinical indications of Sanguan (, and , three places at the wrist where the pulse is usually taken) in classical book ()].

According to indications of Sanguan (, and , three places at the wrist where the pulse is usually taken) described in book (), the selection of acupoints is based on the location of problems and pulse conditions. WANG Shu-he (201-280, a well-known physician of the Wei and Jin dynasties) chose the operation method and stimulating intensity according to the nature of clinical disorders, that is, performing acupuncture or moxibusion in accordance with pulse conditions, or performing reinforcing or reducing needling manipulations based on pulse conditions. Clinical indications of Sanguan described in originate from (: ) and are also influenced by () and ().

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.

Alzheimer's disease (AD) is a widespread neurodegenerative disease caused by complicated disease-causing factors. Unsatisfactorily, curative effects of approved anti-AD drugs were not good enough due to their actions on single-target, which led to desperate requirements for more effective drug therapies involved in multiple pathomechanisms of AD. The anti-AD effect with multiple action targets of Kai-Xin-San (KXS), a classic prescription initially recorded in and applied in the treatment of dementia for thousands of years, was deciphered with modern biological methods in our study.

Characterizing the metabolites and the microbial communities of the soy sauce mash affected by temperature and hydrostatic pressure.

The effect of hydrostatic pressure (HSP) and constant temperature fermentation (CTF) on the microbial community of soy sauce mash and metabolites (volatile and non-volatile) in raw soy sauce were investigated by multiphase methods. Soy sauce inoculated with yeasts (YG) or a mixture of yeasts and bacteria (MYG) were used in the present research. The results suggested that the effect of HSP resulted in decreasing of fungal community diversity, while CTF caused changes of the evenness of fungi species, which were also confirmed by alpha/beta diversity and clustering analysis.

Effect of raw material and starters on the metabolite constituents and microbial community diversity of fermented soy sauce.

Background: The quality of soy sauce is strongly affected by microorganisms and raw materials (defatted soybean or whole soybean). The present study investigated the effect of two types of fortified pattern, including inoculation with starters (Tetragenococcus halophilus combined with Zygosaccharomyces rouxii and Candida versatilis), and adding culture medium (saccharified rice flour solution), on the metabolite profiles and microbial community of soy sauce produced from defatted soybean (DP) and whole soybean (HD). Relationships between microbes and volatiles, and their interactions, were shown.

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Na1.7.

Scorpion toxins are invaluable source of therapeutic leads and pharmacological tools which produce influence on the voltage gated sodium channels. In the previous study, our group has reported BmK AGP-SYPU1 (64 amino acids), one scorpion toxin with both potential α-type and β-type scorpion characteristics and analgesic activity in vivo, act as an activator to hNa1.4 and hNa1.

The Functional Property Changes of Muscular Na(v)1.4 and Cardiac Na(v)1.5 Induced by Scorpion Toxin BmK AGP-SYPU1 Mutants Y42F and Y5F.

Scorpion toxins are invaluable therapeutic leads and pharmacological tools which influence the voltage-gated sodium channels. However, the details were still unclear about the structure-function relationship of scorpion toxins on VGSC subtypes. In the previous study, we reported one α-type scorpion toxin Bmk AGP-SYPU1 and its two mutants (Y5F and Y42F) which had been demonstrated to ease pain in mice acetic acid writhing test.

Evaluation of ischemia-modified albumin and C-reactive protein in type 2 diabetics with and without ketosis.

Overview: To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis.

Approach: One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis.