Publications by authors named "Jin-Yan Zhu"
This study explored the protective effect of atractylenolide â… (AO-â… ) against acetaminophen(APAP)-induced acute liver injury(ALI) in mice and its underlying mechanism. C57 BL/6 J mice were randomly divided into a control group, an APAP group(500 mg·kg~(-1)), a low-dose combination group(500 mg·kg~(-1) APAP + 60 mg·kg~(-1) AO-â… ), and a high-dose combination group(500 mg·kg~(-1) APAP + 120 mg·kg~(-1) AO-â… ). ALI was induced by intraperitoneal injection of APAP(500 mg·kg~(-1)).
View Article and Find Full Text PDFBackground: Long noncoding RNAs (lncRNAs) play important roles in competing endogenous RNA (ceRNA) networks involved in the development and progression of various cancers, including muscle-invasive bladder cancer (MIBC).
Purpose: This study aims to construct the lncRNA-associated ceRNA network and identify lncRNA signatures correlated with the clinical features of MIBC tissue samples from The Cancer Genome Atlas (TGCA) database.
Methods: The differential expression profiles of MIBC associated lncRNAs, miRNAs and mRNAs were obtained from TCGA.
Article Synopsis
- Long non-coding RNAs (lncRNAs) are important epigenetic regulators in plants, influencing growth, development, and responses to stress, yet their role in rice's defense against a specific bacterial disease remains unclear.* -
- The study utilized RNA sequencing to identify 4709 lncRNAs, revealing that 2518 were up-regulated and 2191 down-regulated in response to bacterial infection, suggesting significant changes in gene expression.* -
- Further analysis showed that five lncRNAs increased in expression while their corresponding target genes decreased, indicating that lncRNAs may help regulate immune responses in rice by modulating target genes and miRNA activity.*