Publications by authors named "Jin-Xiu Song"
Article Synopsis
- Caspase-12 is a protein linked to cell death and inflammation, and this study explored its expression in brain cells using specially bred reporter mice.
- Researchers found that caspase-12 is specifically expressed in Purkinje neurons but did not impact the structure of the cerebellum or the number of these cells.
- Mice lacking caspase-12 displayed signs of depression and hyperactivity, suggesting its role in mood regulation, and underlying mechanisms involved reduced signaling through a specific neurotrophic factor pathway.
Ischemic accumulation of succinate causes cerebral damage by excess production of reactive oxygen species. However, it is unknown whether ischemic accumulation of succinate affects neural stem cell proliferation. In this study, we established a rat model of cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery.
View Article and Find Full Text PDFPlant exosome-like nanoparticles (ELNs) have shown great potential in treating tumor and inflammatory diseases, but the neuroprotective effect of plant ELNs remains unknown. In the present study, we isolated and characterized novel ELNs from (MC) and investigated their neuroprotective effects against cerebral ischemia-reperfusion injury. In the present study, MC-ELNs were isolated by ultracentrifugation and characterized.
View Article and Find Full Text PDFBlood-brain barrier (BBB) dysfunction causing edema and hemorrhagic transformation is one of the pathophysiological characteristics of stroke. Protection of BBB integrity has shown great potential in improving stroke outcome. Here, we assessed the efficacy of exosomes extracted from healthy rat serum in protection against ischemic stroke and .
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