Publications by authors named "Jin-Xiu Lyu"
Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases.
Rev Cardiovasc Med
February 2024
Article Synopsis
- * The review highlights several myokines, such as myostatin and irisin, and their varying levels at different stages of CVD, including conditions like heart failure and hypertension.
- * It also explores potential clinical applications of myokines as biomarkers for CVD and discusses challenges in making these research findings applicable in real-world healthcare settings.
Cardiac lipotoxicity is a prevalent consequence of lipid metabolism disorders occurring in cardiomyocytes, which in turn precipitates the onset of heart failure. Mimetics of brain-derived neurotrophic factor (BDNF), such as 7,8-dihydroxyflavone (DHF) and 7,8,3'-trihydroxyflavone (THF), have demonstrated significant cardioprotective effects. However, it remains unclear whether these mimetics can protect cardiomyocytes against lipotoxicity.
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