Publications by authors named "Jin-Wei Tian"
Background: Cardiac hypertrophy and its associated remodeling are among the leading causes of heart failure. Lysine crotonylation is a recently discovered posttranslational modification whose role in cardiac hypertrophy remains largely unknown. NAE1 (NEDD8 [neural precursor cell expressed developmentally downregulated protein 8]-activating enzyme E1 regulatory subunit) is mainly involved in the neddylation modification of protein targets.
View Article and Find Full Text PDFBackground: High-resolution mapping offers superior accuracy in delineating conduction features; however, certain characteristics are still linked to elevated recurrence rates of atrial tachycardia (AT), suggesting the influence of additional mechanisms. This study systematically assessed the substrate of functional conduction block (FCB) regions in relation to the mechanisms of multiple ATs.
Methods: In this study, the Carto system facilitated the mapping of ATs in 13 patients undergoing ablation, each presenting with more than two AT variants.
Article Synopsis
- PIWI-interacting RNAs (piRNAs) play a significant role in cardiovascular diseases, but their involvement in cardiomyocyte death from ischemia/reperfusion (I/R) injury, particularly necroptosis, is not well understood.
- * A specific piRNA, called heart necroptosis-associated piRNA (HNEAP), has been identified as regulating necroptosis in cardiomyocytes by affecting DNA methylation of Atf7 mRNA through DNMT1.
- * Elevated levels of HNEAP were found in damaged heart tissue, and inhibiting its action improved heart function, suggesting that targeting the HNEAP-DNMT1-ATF7-CHMP2A pathway could provide new treatments
PIWI-interacting RNAs (piRNAs) are abundantly expressed in heart. However, their functions and molecular mechanisms during myocardial infarction remain unknown. Here, a heart-apoptosis-associated piRNA (HAAPIR), which regulates cardiomyocyte apoptosis by targeting N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac C) acetylation of transcription factor EC (Tfec) mRNA transcript, is identified.
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- The study focuses on identifying risk factors for early stent thrombosis (EST) in Chinese patients after coronary interventions.
- It involved analyzing data from 426 patients, highlighting that low hemoglobin levels, high SYNTAX scores, and short durations of dual antiplatelet therapy (DAPT) are linked to increased EST risk.
- A new scoring system developed shows strong predictive capability, potentially aiding clinicians in assessing EST risk in patients post-procedure.
Article Synopsis
- Serum uric acid is linked to cardiovascular disease (CVD) risk and may be influenced by vitamin D levels, with low vitamin D potentially increasing uric acid and CVD risk.
- A study analyzed data from 15,723 US adults (aged 20-85) to examine the relationship between vitamin D (both serum levels and dietary intake) and hyperuricemia (HU). The study found that higher serum 25(OH) D and total vitamin D intake were associated with lower odds of HU in males, while females showed a similar trend but no significant link with supplemental vitamin D intake.
- The results suggest that maintaining adequate vitamin D levels could play a protective role against hyperuricemia, particularly in men, while
Application of targeted therapy strategies with nanomedicine delivery for atherosclerosis.
Acta Pharmacol Sin
January 2021
Atherosclerosis (AS) is the main pathological cause of coronary heart disease (CHD). Current clinical interventions including statin drugs can effectively reduce acute myocardial infarction and stroke to some extent, but residual risk remains high. The current clinical treatment regimens are relatively effective for early atherosclerotic plaques and can even reverse their progression.
View Article and Find Full Text PDFCardiac fibrosis is a common pathological condition that contributes to the progression of many cardiac diseases. Circular RNAs (circRNAs) are emerging as new regulators of cardiac fibrosis. However, the expression and function of circRNAs in cardiac fibrosis remain largely unknown.
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