Publications by authors named "Jin-Tae Hong"
Article Synopsis
- This study focused on how the adenosine A3 receptor (A3AR) influences the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) through the regulation of immune cells, particularly pro-inflammatory Kupffer cells derived from monocytes (MoKCs).
- Researchers found that inhibiting A3AR, either through a drug called FM101 or by genetic deletion, significantly improved liver inflammation and fibrosis in model mice.
- The results suggest that targeting A3AR may offer a novel therapeutic approach for treating MASLD by inducing cell death (necroptosis) in harmful immune cells, thereby promoting a healthier liver environment.
Int J Mol Sci
November 2024
Article Synopsis
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where hyper-activated B cells produce autoantibodies, causing symptoms.
- Research found that naïve mesenchymal stem cells (MSCs) inhibit T cell activity but not B cell IgM production, leading to a study on how to enhance MSC function.
- Treatment with ingenol-3-angelate (I3A) primes MSCs to inhibit B cells through the secretion of TGF-β1, showing improved effectiveness in alleviating SLE symptoms in mice.
Int J Mol Med
February 2025
Article Synopsis
- An interested reader pointed out that images in Fig. 5 of the article closely resembled data from a previous paper by the same authors, prompting a re-examination.
- The authors confirmed that an error occurred during submission, resulting in the wrong Fig. 5 and Table II being published, and they have provided the correct versions in the corrigendum.
- Despite these errors, the overall conclusions of the paper remain unaffected, and the authors express gratitude to the Editor for the opportunity to correct the record and apologize for any confusion caused.
Int J Mol Sci
October 2024
Article Synopsis
- IL-32γ plays a crucial role in inhibiting growth and migration of liver cancer cells (HepG2 and Hep3B) while inducing autophagy, as shown by increased LC3 and related markers.
- Through big data analysis, the study revealed that IL-32γ overexpression reduces the expression of MET and mTOR, which are important for tumor growth regulation.
- In vivo experiments confirmed that IL-32γ overexpression leads to suppressed liver tumor growth and correlates with autophagy induction in human liver tumor samples.
Theranostics
October 2024
Article Synopsis
- The article referenced is being corrected to address errors or updates that have been identified after its initial publication.
- The DOI (Digital Object Identifier) serves as a permanent link for accessing this specific article.
- Corrections are important for maintaining the accuracy and reliability of scientific literature.
Article Synopsis
- Keratinocytes are negatively affected by airborne particulate matter (PM), leading to skin barrier issues and inflammation.
- The study investigated the effects of 7S MaR1, a compound derived from fatty acids, on skin inflammation and oxidative stress caused by PM10 in human skin cells.
- Results showed that 7S MaR1 helps reduce harmful ROS (reactive oxygen species) and inflammatory markers, suggesting its potential role in alleviating skin damage from particulate matter exposure.
Int J Mol Sci
September 2024
Article Synopsis
- * Gene expression analysis revealed 1237 genes were upregulated and 1292 genes downregulated in C3 KO mice, with specific genes related to constipation identified.
- * The research highlights a novel gene candidate that may help understand and potentially treat constipation linked to C3 deficiencies, particularly through the modulation of mucin-related gene expression.
Cell Biol Toxicol
August 2024
Article Synopsis
- The combined use of alcohol and cocaine leads to more significant and unpredictable liver, heart, and brain damage compared to using either substance alone.
- Research involving marmosets and mice demonstrated that using both substances together caused worse liver injury and inflammation than individual use did.
- The study identifies hippuric acid as a critical metabolite linked to increased liver damage through inflammation pathways, suggesting that targeting the HA-STING-TNFR1 signaling axis could be a promising treatment for alcohol- and cocaine-related liver injuries.
Mol Ther Nucleic Acids
September 2024
Article Synopsis
- This text indicates that the article with the DOI 10.1016/j.omtn.2019.02.007 is being retracted.
- A retraction means that the article is no longer considered valid or reliable for reference.
- Readers should avoid using this article for their research or citations.
Article Synopsis
- This text refers to a correction made for an article labeled e22 in volume 21, identified by the PubMed ID 34277112.
- The correction is meant to address errors or updates related to the original article.
- It's important for maintaining the accuracy and reliability of published research.
Article Synopsis
- The tumor microenvironment (TME) contains various immune cells, particularly tumor-associated macrophages (TAMs), which play roles in promoting cancer progression.
- A mutated variant of IL-32θ found in breast cancer tissues has been shown to inhibit cancer cell migration and growth via specific intracellular mechanisms.
- Recombinant human IL-32θ (rhIL-32θ) enhances the expression of M1 macrophage markers and suppresses M2 markers, indicating its role in macrophage polarization through the MAPK and NF-κB signaling pathways.
Article Synopsis
- * Recent studies show that ESM can significantly reduce joint pain and slow cartilage damage in animal models of OA when taken before and after inducing the condition.
- * ESM appears to work by inhibiting inflammatory markers and enzymes that contribute to cartilage degradation, especially early in the disease's progression, but its effectiveness diminishes in later stages.
Article Synopsis
- Elevated levels of Chitinase-3-like 1 (CHI3L1) are linked to Alzheimer's Disease (AD) and various other conditions like cancer and neurological disorders, although its exact role in AD remains uncertain.
- A study using CHI3L1-inhibiting compounds showed promise in improving cognitive function and reducing neuroinflammation in AD mouse models.
- Research indicates that CHI3L1 levels are significantly higher in AD patients, and its deficiency in mice led to reduced memory impairment and inflammation, suggesting CHI3L1 may play a crucial role in AD pathology through the ERK-dependent PTX3 pathway.
Br J Pharmacol
September 2024
Article Synopsis
- The study investigates the role of anti-CHI3L1 antibodies in preventing skin inflammation caused by chitinase-3-like 1 (CHI3L1) during atopic dermatitis development.
- Results showed that the antibodies reduced symptoms like epidermal thickening and inflammatory cytokine levels in both animal models and reconstructed human skin.
- The findings suggest that targeting CHI3L1 could be a promising therapy for atopic dermatitis, potentially more effective than existing treatments like IL-4 antibodies.
Int J Biol Macromol
June 2024
Article Synopsis
- Alzheimer's disease (AD) is increasingly prevalent, has significant economic and societal impacts, and currently lacks curative treatments, similar to the situation with cancer.
- Both AD and cancer share biological features such as cell-cycle dysregulation and DNA damage, yet the genetic links between the two have not been thoroughly investigated.
- The review explores shared biological traits, examines anticancer drugs and their potential effects on AD, and discusses innovative therapeutic strategies like immunotherapy and gene therapy to tackle both diseases.
Arch Pharm Res
April 2024
Article Synopsis
- The relationship between schizophrenia and cancer development is debated, with the tumor necrosis factor receptor (TNFR) potentially playing a key role in both conditions.
- Studies on TNFR2 knockout mice showed reduced tumor size and schizophrenia-like behaviors, indicating TNFR2's impact on these diseases.
- The administration of brain-derived neurotrophic factor (BDNF) in TNFR2 knockout mice increased tumor growth and schizophrenia-like behaviors, suggesting that TNFR2 mediates the link between lung cancer and schizophrenia through TrkB-dependent BDNF levels.
Int J Biol Sci
March 2024
Article Synopsis
- MC1R is a receptor in melanocytes that regulates melanin production via α-MSH, while TLR4, found in various cell types, activates immune responses and also enhances melanin production through the NF-κB pathway.
- Benzimidazole-2-butanol (BI2B) has been identified as an inhibitor of the LPS/TLR4 pathway and shows potential in reducing excess pigmentation by targeting the α-MSH-induced melanogenic process.
- In tests involving UV-B-irradiated mouse skin and activated melanocyte cultures, BI2B effectively decreased levels of melanogenic markers and disrupted key signaling pathways linked to pigmentation, highlighting its role in managing hyperpigmentation.
Article Synopsis
- Sphingolipids play a crucial role in regulating insulin signaling, with implications in insulin resistance and diabetes development.
- Treatment with GT-11, an inhibitor, reduced Akt phosphorylation and glucose uptake in C2C12 myotubes, suggesting that modulation of sphingolipid levels affects insulin activity.
- The study indicated that targeting sphingolipid metabolism, particularly through S1P lyase, could have therapeutic potential for managing diabetes mellitus.
Exp Mol Med
February 2024
Article Synopsis
- Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein involved in processes like inflammation, apoptosis, and cancer development.
- Its expression increases significantly in various conditions, including cancers, Alzheimer's disease, and atherosclerosis, making it a potential marker for disease diagnosis and severity.
- Despite its known proinflammatory effects linked to cytokines, the exact roles of CHI3L1 in inflammatory diseases are still not fully understood, prompting a review of its functions and possible therapeutic targets.
Int Immunopharmacol
December 2023
Article Synopsis
- Sepsis is a critical illness with few treatment options, and STAT3 plays a key role in its inflammatory progression.
- Researchers used a mouse model to show that a compound called MMPP can reduce liver damage and prevent death from sepsis triggered by lipopolysaccharides (LPS).
- MMPP works by inhibiting STAT3-related inflammation and lowering levels of pro-inflammatory markers, making it a promising new treatment for liver sepsis.
