Neuronal MeCP2 in the dentate gyrus regulates mossy fiber sprouting of mice with temporal lobe epilepsy.

Sprouting of mossy fibers, one of the most consistent findings in tissue from patients with mesial temporal lobe epilepsy, exhibits several uncommon axonal growth features and has been considered a paradigmatic example of circuit plasticity that occurs in the adult brain. Clarifying the mechanisms responsible may provide new insight into epileptogenesis as well as axon misguidance in the central nervous system. Methyl-CpG-binding protein 2 (MeCP2) binds to methylated genomic DNA to regulate a range of physiological functions implicated in neuronal development and adult synaptic plasticity.

The characteristics of the urogenital fascia in the retrorectal space based on male cadaveric dissection and its clinical application.

Background: The architecture of retrorectal fasciae is complex, as determined by different anatomical concepts. The aim of this study was to examine the anatomical characteristics of the inferomedial extension of the urogenital fascia (UGF) involving the pelvis to explore its relationship with the adjacent fasciae. Furthermore, we have expounded on the clinical application of UGF.

The "Y"-shaped Denonvilliers' fascia and its adjacent relationship with the urogenital fascia based on a male cadaveric anatomical study.

Background: Controversies regarding the anatomical structure of Denonvilliers' fascia and its relationship with surrounding fasciae have sparked a heated discussion, especially concerning whether Denonvilliers' fascia is multilayered. This study aimed to expound on the anatomical structure of Denonvilliers' fascia and its correlation with the peritoneum from the sagittal view and clarify the complex fascial relationship.

Methods: Our study was performed on 20 adult male pelvic specimens fixed in formalin, including 2 entire pelvic specimens and 18 semipelvic specimens.

LKB1 inhibits proliferation, metastasis and angiogenesis of thyroid cancer by upregulating SIK1.

Liver kinase B1 (LKB1), also known as serine/threonine kinase 11, was considered as a tumor suppressor, which exhibited anti-cancer activity in a variety of cancers. However, the effect of LKB1 in thyroid cancer remains unclear. In the study, MTT assay, colony formation assay, flow cytometry, western blot analysis, wound healing assay, transwell assays, quantitative real-time PCR, HUVEC migration assay, ELISA assay, tube formation assay and nude mice xenograft were used to investigate the anti-cancer capacity of LKB1 in thyroid cancer and .

Neuronal Glypican4 promotes mossy fiber sprouting through the mTOR pathway after pilocarpine-induced status epilepticus in mice.

In temporal lobe epilepsy (TLE), abnormal axon guidance and synapse formation lead to sprouting of mossy fibers in the hippocampus, which is one of the most consistent pathological findings in patients and animal models with TLE. Glypican 4 (Gpc4) belongs to the heparan sulfate proteoglycan family, which play an important role in axon guidance and excitatory synapse formation. However, the role of Gpc4 in the development of mossy fibers sprouting (MFS) and its underlying mechanism remain unknown.

Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus.

MicroRNAs (miRNA) are believed to play a crucial role in the cause and treatment of temporal lobe epilepsy (TLE) by controlling gene expression in different stages of the disease. To investigate role of miRNA in the latent stage following status epilepticus, we first compared microRNA expression profiles in mice hippocampus at 1 week after pilocarpine-induced status epilepticus (SE) vs. controls in hippocampal tissues using Exiqon miRCURY LNA™ miRNAs Array.

[Percutaneous transforaminal endoscopic TESSYS technique for the treatment of bilateral lumbar disc herniation in single segment].

Objective: To investigate the early clinical effects of transforaminal endoscopic spine system (TESSYS) for the treatment of bilateral lumbar disc herniation in single segment.

Methods: The clinical data of 38 patients with single-segment bilateral lumbar disc herniation treated by TESSYS technique from February 2016 to February 2018 were retrospectively analyzed. There were 26 males and 12 females, aged from 30 to 55 years old with an average of(35.

[Fourier Transform Spectrometer Based on Rotating Parallel-Mirror-Pair].

In the temporally-modulated Fourier transform spectroscopy, the translational moving mirror is difficult to drive accurately, causing tilt and shear problems. While, a rotational moving mirror can solve these problems. A rotary Fourier transform spectrometer is recommanded in this paper.

The association between XRCC1 Arg399Gln polymorphism and risk of leukemia in different populations: a meta-analysis of case-control studies.

Background: Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods.

Methods: A meta-analysis was performed to examine the associations between XRCC1 Arg399-Gln SNP and leukemia risk.

[Study of Spectral Property and Measurement of Linear Variable Filters].

Linear variable filters (LVF) are widely used in a variety of small rapid spectrometric detecting devices. In the present paper, the splitting property of LVF was studied, and the spectral-property expression in Gaussian form was given, and the relationship between indexes of expression and LVF center transmission, width of spectrum, and linear dispersion was specified. Measurement based on monochromator for imaging spectrometers calibration was introduced, the sensitivity for detection system was discussed, and the tolerance was analyzed.

[Measurements of the concentration of atmospheric CO2 based on OP/FTIR method and infrared reflecting scanning Fourier transform spectrometry].

The present paper describes the observations and measurements of the infrared absorption spectra of CO2 on the Earth's surface with OP/FTIR method by employing a mid-infrared reflecting scanning Fourier transform spectrometry, which are the first results produced by the first prototype in China developed by the team of authors. This reflecting scanning Fourier transform spectrometry works in the spectral range 2 100-3 150 cm(-1) with a spectral resolution of 2 cm(-1). Method to measure the atmospheric molecules was described and mathematical proof and quantitative algorithms to retrieve molecular concentration were established.

[Manufacture tolerance analysis of solid Mach-Zehnder interferometer in large aperture static imaging spectrometer (LASIS)].

The principle and instrumental structure of large aperture static imaging spectrometer (LASIS) were briefly described in the present paper, the principle of the Mach-Zehnder imaging spectrometer was introduced, and the Mach-Zehnder interferometers' working way in the imaging spectrometer was illustrated. The structure of solid Mach-Zehnder interferometer was analyzed, and discussion was made based on the requirements of field of view (FOV) in image space and single sided interferogram with a small portion around zero path difference (ZPD). The additional optical path difference (OPD) created by manufacturing and matching tolerance of two asymmetrical pentagonal prisms will lead to the displacement of shearing and OPD nonlinearity.

Ginsenoside Rd attenuates mitochondrial permeability transition and cytochrome C release in isolated spinal cord mitochondria: involvement of kinase-mediated pathways.

Ginsenoside Rd (Rd), one of the main active ingredients in Panax ginseng, has multifunctional activity via different mechanisms and neuroprotective effects that are exerted probably via its antioxidant or free radical scavenger action. However, the effects of Rd on spinal cord mitochondrial dysfunction and underlying mechanisms are still obscure. In this study, we sought to investigate the in vitro effects of Rd on mitochondrial integrity and redox balance in isolated spinal cord mitochondria.

[Design of the airborne prism dispersive imaging spectrometer system based on Offner relay configuration].

Considering the development of the need for small volume and light weight of spectral imaging systems on airborne platform, the characters of several main imaging spectrometers was analyzed and the present paper focuses on introducing imaging spectrometers featuring a grating or a prism disperser. A compact hyperspectral imaging system based on Offner relay configuration is reported. Combining the characters of the concentric Offner relay, and knowing the system design parameters, two novel kinds of spherical spectrometer systems using dispersive elements in divergent and convergent beam were designed.

Correlation of Sperm Associated Antigen 11 (SPAG11) and its Isoforms with Varicocele in Rats.

Background: We undertook this study to investigate the variation relationship of sperm associated antigen 11 (Spag11) mRNA expression and SPAG11E protein in the epididymis and spermatozoa of experimental left varicocele (ELV) rats. These findings could contribute to the understanding of the role of epididymal proteins in sperm functions and the mechanism of male infertility induced by varicocele.

Methods: The ELV model was established in adolescent male Sprague-Dawley rats.

[A wide-field push-broom hyperspectral imager based on curved prism].

A wide-field pushbroom hyperspectral imager covering short-wavelength infrared range is presented, which can be carried by space borne or airborne platform for remote sensing, acquiring hyperspectral data cube, and analyzing substance compositions and physicochemical properties. Curved prism which simultaneously possesses the functions of dispersion and imaging is used as the prismatic element, and the combination with Offner relay configuration substantially simplifies the design of spectrometer. Compared to conventional dispersive spectral imagers, this design is compact, light-weighted, and small-sized, and can efficiently correct unavoidable spectral line curve (smile) and spectral band (keystone or frown) by prismatic dispersion Compared to grating spectral imagers of the same configuration, the energy utilization efficiency of this design is much higher.

[Modeling and correction of the effect of detector lateral fringe error in the large aperture static imaging spectrometer].

When the large aperture static imaging spectrometry (LASIS) was used in spaceborne remote sensing, the spectrum could not be well recovered from the interferogram with detector lateral fringe error. In order to obtain the more accurate spectrum, the error must be corrected. According to the imaging principle analysis of LASIS, the imaging model with lateral fringe error was given, and the error correction method was presented.

[Advance in imaging spectropolarimeter].

Imaging spectropolarimeter (ISP) is a type of novel photoelectric sensor which integrated the functions of imaging, spectrometry and polarimetry. In the present paper, the concept of the ISP is introduced, and the advances in ISP at home and abroad in recent years is reviewed. The principles of ISPs based on novel devices, such as acousto-optic tunable filter (AOTF) and liquid crystal tunable filter (LCTF), are illustrated.

[Advance in interferogram data processing technique].

Fourier transform spectrometry is a type of novel information obtaining technology, which integrated the functions of imaging and spectra, but the data that the instrument acquired is the interference data of the target, which is an intermediate data and couldn't be used directly, so data processing must be adopted for the successful application of the interferometric data In the present paper, data processing techniques are divided into two classes: general-purpose and special-type. First, the advance in universal interferometric data processing technique is introduced, then the special-type interferometric data extracting method and data processing technique is illustrated according to the classification of Fourier transform spectroscopy. Finally, the trends of interferogram data processing technique are discussed.