Crystalline Liquiritigenin and Liquiritin: Structural Characterization, Molecular Docking Studies, and Anti-Amyloid-β Evaluation in .

Two new crystalline compounds, named [LG·HO] (; LG = liquiritigenin) and [LQ·CHOH·HO] (; LQ = liquiritin), have been synthesized and structurally characterized by single-crystal and powder X-ray diffraction, thermogravimetric analyses (TGA), nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and infrared spectra (IR). and crystallize in space groups na2 and 222, respectively. In the structure of , liquiritigenin and water molecules are connected by hydrogen bonds for the construction of a novel 3,5-connected network topology with a point symbol of (6)(6·8), in which each liquiritigenin and water molecule acts as a 5-connected and 3-connected node, respectively.

[Expressions of HLA class I antigen and CD8 and their clinical significance in cervical cancer].

Objective: To examine the expressions of HLA class I antigen and CD8 in various cervical diseases and investigate their association with cervical cancer.

Methods: The expressions of HLA class I antigen and CD8 in cervical tissues sampled from patients with cervical cancer, cervical intraepithelial neoplasia (CIN), and chronic cervicitis were detected using SP immunohistochemistry. The association of the expressions of HLA class I antigen and CD8 with the clinicopathologic indices of the patients was analyzed.