Publications by authors named "Jin-Rui Hu"
Background: Ankyrin repeat domain 49 (ANKRD49) has been found to be highly expressed in multiple cancer including lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC). However, the function of ANKRD49 in the pathogenesis of NSCLC still remains elusive. Previously, ANKRD49 has been demonstrated to promote the invasion and metastasis of A549 cells, a LUAD cell line, via activating the p38-ATF-2-MMP2/MMP9 pathways.
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- A study was conducted in Shanghai to investigate the prevalence, genetic diversity, antibiotic resistance, and pathogenicity of strains isolated from food, as these strains have been recognized as emerging human pathogens associated with diarrhea worldwide.
- A total of 79 food isolates were analyzed, revealing eight different species, with most being hemolytic and showing antibiotic resistance; specifically, 11.4% were multidrug-resistant and 93.7% were resistant to cefazolin.
- The findings indicate that certain isolates are highly pathogenic, posing risks to public health, and emphasize the importance of monitoring food safety to improve prevention and treatment of diarrhea-related illnesses in China.
Backgruound: It is well-established that serum testosterone in men decreases with age, yet the underlying mechanism of this change remains elusive.
Methods: The expression patterns of Fancd2 opposite-strand (Fancd2os) in BALB/c male mice and testicular tissue derived cell lines (GC-1, GC-2, TM3, and TM4) were assessed using real-time polymerase chain reaction (RT-PCR), Western blot and immunofluorescence. The Fancd2os-overexpressing or knockdown TM3 cells were constructed by infecting them with lentivirus particles and were used to evaluated the function of Fancd2os.
Objective: This study was performed to compare the genetic diversity, virulence, and antimicrobial resistance of strains isolated from patients and healthy individuals.
Methods: A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma'anshan City, Anhui Province. Their taxonomy was investigated using concatenated - sequences, and their resistance to 12 antibiotics was evaluated.
Toxoplasma gondii ROP17 promotes autophagy via the Bcl-2-Beclin 1 pathway.
Folia Parasitol (Praha)
June 2021
The apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908) secretes a group of serine/threonine kinases from rhoptries, which play vital roles in boosting intracellular infection. Toxoplasma gondii rhoptry organelle protein 17 (ROP17) is one of these important kinase proteins. Nevertheless, its function remains unclear.
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