Synthesis, G-Quadruplex DNA binding and cytotoxic properties of naphthalimide substituted styryl dyes.

G-Quadruplex DNAs, formed by G-rich DNA sequences in human genes, are promising targets for design of cancer drugs. In this study, two naphthalimide substituted styryl dyes with different sizes of aromatic groups were synthesized. The spectral analysis showed that the dye X-2 with a large aromatic group formed aggregates in buffer solution displaying very weak fluorescence intensity, and disaggregated in the presence of G-Quadruplex DNAs with large intensity enhancements (up to ~1800 fold).

[Simultaneous determination of four anthraquinones in rat plasma by HPLC-FLD method and its pharmacokinetic study].

This paper aims to develop a method for the determination of aloe-emodin, rhein, chrysophanol and physcion and study the pharmacokinetic properties of four anthraquinones in rat plasma after oral administration of gardenia and rhubarb decoction. The plasma concentrations at different time points of four anthraquinones were determined by HPLC-FLD method. Plasma samples were extracted with liquid-liquid extraction procedure.

[Clinical study of lymph node metastatic pattern of thoracic esophageal squamous carcinoma].

Objective: To analyze the patterns of lymph node metastases of thoracic esophageal carcinoma and define the adequate range of lymph node dissection.

Methods: The clinical data of 217 patients with esophageal carcinoma undergoing radical surgical resection of the lymph nodes in three regions were retrospectively analyzed.

Results: Lymph node metastases were found in 136 of the 217 patients (62.

[Analysis of lymph node metastases of 217 cases of thoracic esophageal carcinoma and its impact on prognosis].

Background & Objective: At present, the range of lymph node dissection in treatment of thoracic esophageal cancer is still controversial. This study was designed to explore the status of lymph node metastases of thoracic esophageal carcinoma and its influence on the prognosis and to seek reasonable dissecting range of lymph nodes.

Methods: A retrospective study was performed on the clinical data of 217 patients who had underwent radical operation through three-field lymphadenectomy.

[A prospective study of combined chemoradiotherapy followed by surgery in the treatment of esophageal carcinoma].

Objective: To evaluate the effect of combined chemoradiotherapy followed by surgery for patients with esophageal carcinoma.

Methods: Ninety-seven patients with stage II or III esophageal carcinoma without contraindication against operation and chemoradiotherapy, were randomly divided into two groups: combined group (Group A) 48 and control group (Group B) 49. Patients in group A were given neoadjuvant treatment consisted of chemotherapy with 5-fluorouracil and cisplatin for 2 cycles and radiotherapy of DT36 Gy/12 f/17 d.