[Expression of Twist in papillary thyroid carcinomas and its roles in differential diagnosis].

Objective: To study Twist expression in thyroid papillary carcinoma (PTC) by immunohistochemistry and to assess its usefulness as marker in the differential diagnosis of PTC, follicular adenomas (FA) and benign papillary lesions (BPL).

Methods: Fifty cases of PTC, 48 cases of FA and 47 cases of BPL were evaluated using manual tissue chip and SP immunohistochemical stain to detect the expression of Twist and HBME-1, and comparing the staining to that of cytokeratin 19 (CK19).

Results: In PTC, positive rates of Twist, HBME-1 and CK19 were 100% (48/48), 94.