Publications by authors named "Jin-Myung Kim"

Article Synopsis
  • Robot-assisted kidney transplantation (RAKT) is gaining popularity, but there's limited research on its effectiveness for immunologically high-risk patients, particularly those with ABO incompatibility (ABOi), compared to traditional open kidney transplantation (OKT).
  • A study involving 239 living-donor transplants compared 210 ABOi-OKT cases with 29 ABOi-RAKT cases, using statistical methods to ensure valid comparisons and analyze outcomes like acute rejection and graft failure.
  • Results showed similar one- and two-year survival rates and kidney function between RAKT and OKT, but RAKT had longer surgery times and cold ischemic periods, while hospital stays were shorter for RAKT, indicating it is a safe and effective
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Background: Clinical manifestations and risk factors associated with systemic lupus erythematosus (SLE) flares, including recurrent lupus nephritis (LN), in patients with LN who undergo kidney transplantation have been unclear.

Methods: Kidney transplant recipients with LN from January 1995 to December 2021 were included in this study. A disease flare was defined as either an increase in the non-renal SLE disease activity index score or the presence of biopsy-proven recurrent LN.

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  • The study investigates how kidney fibrosis from deceased donors affects transplant success and aims to find miRNA biomarkers in urinary exosomes that correlate with interstitial fibrosis and tubular atrophy (IFTA) severity.
  • Out of 109 urine samples analyzed, 34 showed no IFTA while 75 had varying degrees of IFTA, with six specific miRNAs identified as potential biomarkers.
  • Notably, miR-21 and miR-29c demonstrated strong predictive accuracy for IFTA, and the study found that kidney function (eGFR) was significantly better in the no IFTA group compared to the IFTA group one week post-transplant.
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Background: Accurate forecasting of clinical outcomes after kidney transplantation is essential for improving patient care and increasing the success rates of transplants. The authors' study employs advanced machine learning (ML) algorithms to identify crucial prognostic indicators for kidney transplantation. By analyzing complex datasets with ML models, the authors aim to enhance prediction accuracy and provide valuable insights to support clinical decision-making.

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The quest to reduce kidney transplant rejection has emphasized the urgent requirement for the development of non-invasive, precise diagnostic technologies. These technologies aim to detect antibody-mediated rejection (ABMR) and T-cell-mediated rejection (TCMR), which are asymptomatic and pose a risk of potential kidney damage. The protocols for managing rejection caused by ABMR and TCMR differ, and diagnosis has traditionally relied on invasive biopsy procedures.

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To explore the potential of probiotic candidates beneficial for honeybee health through the modulation of the gut microbiome, bee gut microbes were isolated from bumblebee (Bombus terrestris) and honeybee (Apis mellifera) using diverse media and cultural conditions. A total of 77 bee gut bacteria, classified under the phyla Proteobacteria, Firmicutes, and Actinobacteria, were identified. The antagonistic activity of the isolates against Ascosphaera apis, a fungal pathogen responsible for chalkbrood disease in honeybee larvae, was investigated.

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  • This study examines the outcomes of kidney transplantation in patients who have also received a liver transplant (LTKT) versus those who only had kidney transplants (KTA) from 2005 to 2020.
  • It included 4312 patients, with 44 in the LTKT group and 4268 in the KTA group, and used statistical methods to balance the groups for fair comparison.
  • The results showed no significant difference in graft survival rates, but the LTKT patients experienced better rejection-free survival than the KTA group.
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Although Si is extensively used in micro-nano electronics, its inherent optical absorption cutoff at 1100-nm limits its photonic and optoelectronic applications in visible to partly near infrared (NIR) spectral range. Recently, strain engineering has emerged as a promising approach for extending device functionality via tuning the material properties, including change in optical bandgap. In this study, the reduction in bandgap with applied strain was used for extending the absorption limit of crystalline Si up to 1310 nm beyond its intrinsic bandgap, which was achieved by creating the crumpled structures in Si nanomembranes (NMs).

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To date, controlled deformation of two-dimensional (2D) materials has been extensively demonstrated with substrate-supported structures. However, interfacial effects arising from these supporting materials may suppress or alter the unique behavior of the deformed 2D materials. To address interfacial effects, we report, for the first time, the formation of a micrometer-scale freestanding wrinkled structure of 2D material without any encapsulation layers where we observed the enhanced light-matter interactions with a spatial modulation.

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Dynamically controlling friction in micro- and nanoscale devices is possible using applied electrical bias between contacting surfaces, but this can also induce unwanted reactions which can affect device performance. External electric fields provide a way around this limitation by removing the need to apply bias directly between the contacting surfaces. 2D materials are promising candidates for this approach as their properties can be easily tuned by electric fields and they can be straightforwardly used as surface coatings.

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Kaposi's sarcoma (KS) is a disease that is not widely known among the general public, but has a high prevalence among organ transplant recipients. Here, we present a rare case of intragraft KS after kidney transplantation. A 53-year-old woman who had been on hemodialysis due to diabetic nephropathy underwent deceased-donor kidney transplantation on December 7, 2021.

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Article Synopsis
  • Cancer stem cells (CSCs) are a small but significant population of tumor cells that enable tumor growth and recurrence due to their self-renewal and differentiation abilities.
  • CSCs are resistant to standard cancer treatments like chemotherapy and radiotherapy because they have strong antioxidant systems and mechanisms to expel drugs from their cells.
  • The NRF2 transcription factor plays a key role in CSC behavior and treatment resistance by regulating genes that detoxify harmful substances, and its persistent activation in cancers can promote tumor aggressiveness and hinder effective therapies.
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Abundant Li resources in the ocean are promising alternatives to refining ore, whose supplies are limited by the total amount and geopolitical imbalance of reserves in Earth's crust. Despite advances in Li extraction using porous membranes, they require screening other cations on a large scale due to the lack in precise control of pore size and inborn defects. Herein, MoS nanoflakes on a multilayer graphene membrane (MFs-on-MGM) that possess ion channels comprising i) van der Waals interlayer gaps for optimal Li extraction and ii) negatively charged vertical inlets for cation attraction, are reported.

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Simultaneous deceased donor pancreas and living donor kidney transplant (SPLK) has certain advantages over conventional simultaneous pancreas-kidney transplant (SPK) and may be beneficial for overcoming the paucity of organs needed for diabetic patients requiring transplant. We compared the clinical outcomes of patients who underwent either SPK (n = 149) or SPLK (n = 46) in terms of pre- and post-transplantation variables, development of de novo DSA, occurrence of biopsy-proven acute rejection (BPAR), and graft survival rates. There were no significant differences in the baseline characteristics between the SPK and SPLK groups except for the shorter cold ischemic time of kidney grafts, shorter duration of diabetes, older age of pancreas graft-donors, and younger age of kidney graft-donors in the SPLK group.

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Venoms from venomous arthropods, including bees, typically induce an immediate local inflammatory response; however, how venoms acutely elicit inflammatory response and which components induce an inflammatory response remain unknown. Moreover, the presence of superoxide dismutase (SOD3) in venom and its functional link to the acute inflammatory response has not been determined to date. Here, we confirmed that SOD3 in bee venom (bvSOD3) acts as an inducer of HO production to promote acute inflammatory responses.

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Honeybee vitellogenin (Vg) transports pathogen fragments from the gut to the hypopharyngeal glands and is also used by nurse bees to synthesize royal jelly (RJ), which serves as a vehicle for transferring pathogen fragments to the queen and young larvae. The proteomic profile of RJ from bacterial-challenged and control colonies was compared using mass spectrometry; however, the expression changes of major royal jelly proteins (MRJPs) in hypopharyngeal glands of the honeybee in response to bacterial ingestion is not well-characterized. In this study, we investigated the expression patterns of in the fat body and in the hypopharyngeal glands of nurse bees after feeding them live or heat-killed .

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Flexible electrodes that allow electrical conductance to be maintained during mechanical deformation are required for the development of wearable electronics. However, flexible electrodes based on metal thin-films on elastomeric substrates can suffer from complete and unexpected electrical disconnection after the onset of mechanical fracture across the metal. Here we show that the strain-resilient electrical performance of thin-film metal electrodes under multimodal deformation can be enhanced by using a two-dimensional (2D) interlayer.

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Recent discoveries of exotic physical phenomena, such as unconventional superconductivity in magic-angle twisted bilayer graphene, dissipationless Dirac fermions in topological insulators, and quantum spin liquids, have triggered tremendous interest in quantum materials. The macroscopic revelation of quantum mechanical effects in quantum materials is associated with strong electron-electron correlations in the lattice, particularly where materials have reduced dimensionality. Owing to the strong correlations and confined geometry, altering atomic spacing and crystal symmetry via strain has emerged as an effective and versatile pathway for perturbing the subtle equilibrium of quantum states.

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The capillary force can peel off a substrate-attached film if the adhesion energy () is low. Capillary peeling has been used as a convenient, rapid, and nondestructive method for fabricating free-standing thin films. However, the critical value of , which leads to the transition between peeling and sticking, remains largely unknown.

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Sperm storage in the spermathecae of honeybee () queens is vital for reproduction of honeybees. However, the molecular mechanisms whereby queens store sperm in a viable state over prolonged periods in the spermatheca are not fully understood. Here, we conducted RNA sequencing analysis of the spermathecae in both virgin and mated queens 24 h after mating and observed that the genes encoding transferrin (Tf) and major royal jelly proteins (MRJPs) were differentially expressed in the spermathecae of mated queens.

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Understanding modulation of liquid molecule slippage along graphene surfaces is crucial for many promising applications of two-dimensional materials, such as in sensors, nanofluidic devices, and biological systems. Here, we use force measurements by atomic force microscopy (AFM) to directly measure hydrodynamic, solvation, and frictional forces along the graphene plane in seven liquids. The results show that the greater slip lengths correlate with the interfacial ordering of the liquid molecules, which suggests that the ordering of the liquid forming multiple layers promotes slip.

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The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters. In contrast to the protective roles in normal cells, the multifaceted role of NRF2 in tumor growth and progression, resistance to therapy and intratumoral stress, and metabolic adaptation is rapidly expanding, and the complex association of NRF2 with cancer signaling networks is being unveiled. In particular, the implication of NRF2 signaling in cancer stem cells (CSCs), a small population of tumor cells responsible for therapy resistance and tumor relapse, is emerging.

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Single-photon emitters, the basic building blocks of quantum communication and information, have been developed using atomically thin transition metal dichalcogenides (TMDCs). Although the bandgap of TMDCs was spatially engineered in artificially created defects for single-photon emitters, it remains a challenge to precisely align the emitter's dipole moment to optical cavities for the Purcell enhancement. Here, we demonstrate position- and polarization-controlled single-photon emitters in monolayer WSe.

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