Publications by authors named "Jin-Ming Zhang"

Organic photoelectrochemical transistor (OPECT) has emerged as a promising technique for biomolecule detection, yet its operational rationale remains limited due to its short development time. This study introduces a stable tandem catalysis protocol by synergizing the enzyme-incorporated metal-organic frameworks (E-MOFs) with polyoxometalate (POM) nanozyme for sensitive OPECT bioanalysis. The zeolitic imidazolate framework-8 (ZIF-8) acts as the skeleton to protect the encapsulated glucose oxidase (GOx), allowing the stable catalytic generation of HO.

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  • Hsp72 expression increases during the accumulation of triglycerides in both adipose tissue and 3T3-L1 cells, suggesting a role in fat storage.
  • Knocking down Hsp72 reduces the expression of adipogenic genes and triglyceride levels in 3T3-L1 cells, indicating Hsp72 promotes fat cell differentiation and lipid synthesis.
  • Hsp72 inhibitors like YK5 and MKT-077 can disrupt these processes, making them potential candidates for anti-obesity treatments by inhibiting fat cell development and fat storage.
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Objective: Tangbi capsule (TBC) is a traditional Chinese medicine prescription, which has the potential to improve the vascular insufficiency of lower extremities and limb numbness in diabetes. However, the potential mechanism remains unknown. This study aims to investigate the pharmacological effects and mechanism of TBC on rats with diabetic lower extremities arterial disease (LEAD).

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The subscapularis tendon is more challenging and riskier to repair than the posterior upper rotator cuff. The knotless anchor suture in subscapularis repair simplified the repair process and had an excellent postoperative effect. We describe a new knotless anchor stitching method, the H-Loop technique.

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  • Liver transplantation rejection is a significant issue, and the role of myeloid-derived suppressor cells (MDSCs) in this process is not well understood.
  • This study investigated MDSCs by analyzing liver tissues and blood samples from patients and mouse models during varying degrees of rejection, finding a correlation between high rejection levels and increased M-MDSC and PD-1+ T-cell presence.
  • Results revealed that CD84 plays a critical role in regulating M-MDSC functions, promoting T-cell exhaustion and possibly contributing to liver transplant rejection dynamics.
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Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase (RTK) primarily expressed in hematopoietic stem cells and dendritic cells (DCs). While FLT3 plays a critical role in the proliferation, development and maintenance of DCs, thus influencing immune responses under both normal and pathological conditions, there also exists some evidence that FLT3DC may be involved with immune responses in liver transplantation (LT). In this study, results from single-cell sequencing data analysis revealed a clear relationship between FLT3DCs and Regulatory T cells (Tregs) in liver tissue of LT recipients.

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Understanding the polymer solubility in ionic liquids (ILs) is important for polymer processing or polymeric material preparation. Previously, two-parameter H-bonding analysis has been proposed to clarify that polymer solubility in ILs is dominated by H-bonding interactions (Y. F.

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Background: Automatic extraction of roads from remote sensing images can facilitate many practical applications. However, thus far, thousands of kilometers or more of roads worldwide have not been recorded, especially low-grade roads in rural areas. Moreover, rural roads have different shapes and are influenced by complex environments and other interference factors, which has led to a scarcity of dedicated low level category road datasets.

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  • The study aimed to assess the effectiveness and safety of foot baths using Tangbi Waixi Decoction for patients with diabetic peripheral neuropathy (DPN) through a multicenter double-blinded randomized controlled trial.
  • A total of 632 patients participated, receiving either a high or low dose of herbal treatment for two weeks, with results showing improvements in nerve function and reduced pain scores in both groups after 12 weeks.
  • However, the lower dose was found to be more effective than the higher dose, and overall, there were no significant differences in adverse events between the treatment and control groups, indicating the treatment was safe.
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Background: Western medicine is beneficial for the recovery of neurological function in patients with depression, but some patients experience side effects such as headaches, dizziness, nausea, gastrointestinal symptoms, insomnia, and cardiac dysfunction. In recent years, integrative medicine has achieved positive results in the treatment of various diseases.

Aim: To study Chuanjin Qinggan decoction combined with selective serotonin reuptake inhibitors (SSRIs) in patients with herpes zoster complicated by depression.

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Regulation of tumor vessels has become one of the most common strategies for clinical anti-tumor therapy. In recent years, studies have found that the anti-tumor effect of limotherapy, which routinely inhibits tumor angiogenesis, is not ideal and may even deteriorate the tumor microenvironment, causing tumor resistance and distal metastasis and increasing the risk of tumor metastasis and recurrence. However, the proper use of anti-angiogenic drugs can promote the normalization of tumor vessels, improve the structure and function of tumor vessels, increase the number of functional vessels in the tumor, and reduce the number of ineffective vessels.

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Skeletal muscle atrophy is a frequent complication after spinal cord injury (SCI) and can influence the recovery of motor function and metabolism in affected patients. Delaying skeletal muscle atrophy can promote functional recovery in SCI rats. In the present study, we investigated whether a combination of body weight support treadmill training (BWSTT) and glycine and N-acetylcysteine (GlyNAC) could exert neuroprotective effects, promote motor function recovery, and delay skeletal muscle atrophy in rats with SCI, and we assessed the therapeutic effects of the double intervention from both a structural and functional viewpoint.

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The resin ethanol extract of Gegen Qinlian Decoction(GGQLD) has been found to significantly alleviate the intestinal toxicity caused by Irinotecan, but further research is needed to establish its overall quality and clinical medication standards. This study aimed to establish an HPLC characteristic fingerprint of the resin ethanol extract of GGQLD, predicted the targets and signaling pathways of its pharmacological effects based on network pharmacology, identified core compounds with pharmacological relevance, and analyzed potential quality markers(Q-markers) of the resin eluate of GGQLD for relieving Irinotecan-induced toxicity. By considering the uniqueness, measurability, and traceability of Q-markers based on the "five principles" of Q-markers and combining them with network pharmacology techniques, the overall efficacy of the resin ethanol extract of GGQLD can be characterized.

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  • Zollinger-Ellison syndrome (ZES) is caused by gastrin-secreting tumors known as gastrinomas, leading to symptoms like watery diarrhea and ulcers; however, this case presents an atypical scenario.
  • A 72-year-old woman with typical ZES symptoms had normal gastrin levels and no visible gastrinoma during initial examinations, complicating her diagnosis.
  • The use of a new imaging technique, 18F-OC PET/CT, ultimately identified a gastrinoma at an unusual site, highlighting the potential for ZES symptoms even in the absence of hypergastrinemia.
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This study compared the chemical profiles, component content, dry paste yield, and pharmacological effects of samples obtained from the mixed single decoctions and the combined decoction of Gegen Qinlian Decoction(GQD), aiming to provide an experimental foundation for evaluating the equivalence of the two decocting methods and the suitability of TCM formula granules in clinical application. The same decoction process was used to prepare the combined decoction and mixed single decoctions of GQD. Ultra-performance liquid chromatography coupled with Q-Exactive Orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap MS) was employed to compare the chemical profiles between the two groups.

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The most frequent operation for anterior shoulder instability is the arthroscopic Bankart repair, which has a positive outcome and a low rate of complications. A variety of restoration procedures have been reported to reconstruct labral height and reproduce a dynamic concavity-compression reaction. The longitude-latitude loop is a knotless high-strength suture method that simultaneously tightens the joint capsule in the warp and weft direction and resists tearing.

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In this study, we introduce an arthroscopic technique for posterior-superior capsular fenestration and spinoglenoid cyst resection completely via a trans-rotator cuff approach. This approach can provide a full field of view and allow evaluation of the scope of the cyst under direct vision, which reduces the risk of recurrence and injury to the suprascapular neurovascular bundle.

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Since pro-inflammatory macrophages take on a critical significance in the pathophysiology of rheumatoid arthritis (RA), the therapeutics to affect macrophages may receive distinct anti-RA effects. However, the therapeutic outcomes are still significantly impeded, which is primarily due to the insufficient drug delivery at the arthritic site. In this study, the macrophage-targeting and pH stimuli-responsive nano-polyelectrolyte complexes were designed for the efficient targeted delivery of triptolide (TP/PNPs) on the arthritic site.

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  • Liver transplantation (LT) is a successful treatment for end-stage liver disease, but immune rejection poses a major challenge to patient survival and prognosis.
  • The study utilized a protein chip system and proteomics to analyze serum proinflammatory cytokines and liver tissue proteins in a mouse model, revealing significant changes in cytokine levels post-transplant.
  • Key findings included increased levels of GC-CSF, CXCL-1, MCP-5, and CXCL-2, along with the identification of enriched pathways related to immune responses and specific proteins associated with transplant rejection, suggesting new targets for treatment.
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  • New research highlights the important role of group 2 innate lymphoid cells (ILC2s) in regulating the immune response during liver transplantation (LT), especially in the context of acute rejection.
  • The study found that while the number of circulating ILC2s was similar in transplant patients, those experiencing rejection had significantly higher levels of hepatic ILC2s compared to non-rejecting patients and controls.
  • In a mouse model, ILC2 counts increased dramatically in the liver and bone marrow within the first two weeks post-transplant, indicating that these cells might work alongside regulatory T cells (Tregs) to help manage immune responses and potentially mitigate rejection.
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Hepatic ischemia-reperfusion injury (IRI) is an adverse consequence of hepatectomy or liver transplantation. Recently, immune mechanisms involved in hepatic IRI have attracted increased attention of investigators working in this area. In specific, group 2 innate lymphoid cells (ILC2s), have been strongly implicated in mediating type 2 inflammation.

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Long head of the biceps tendinopathy is a common shoulder problem that is difficult to diagnose and treat. Biceps tenodesis is an effective surgical approach target for long head of the biceps tendon lesions. This article describes an all-arthroscopic proximal biceps tenodesis technique.

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Although double positive CD4CD8 T (DPT) cells has been reported to be involved in some diseases, their trajectory and function as associated with liver transplantation (LT) remain unclear. In the present study, we found that the number of DPT cells was increased in the blood and liver tissue of LT patients. Meanwhile, we compared the distribution of DPT cells in peripheral blood samples and in penetrating liver tissue between liver rejection versus non-rejection patients, as well as the proportion of DPT cells as a function of the extent of liver rejection.

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LRP1, the low-density lipoprotein receptor 1, would be a novel candidate gene of epilepsy according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in epilepsy and whether beta-hydroxybutyrate, the principal ketone body of the ketogenic diet, can treat epilepsy caused by LRP1 deficiency in drosophila. UAS/GAL4 system was used to establish different genotype models.

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