Recent advances of bioresponsive polymeric nanomedicine for cancer therapy.

A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes, and can exert its therapeutic efficacy within a confined space. These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues. Moreover, bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.

Mechanical Properties of Hybrid Fiber Reinforced Rubber Concrete.

Orthogonal experiments were designed for hybrid fiber rubber concrete (HFRC). The mechanical properties of HFRC were tested and compared with ordinary concrete. The effects of basalt fiber volume ratio (), PVA fiber volume ratio () and rubber volume ratio () on the compressive strength, splitting tensile strength and flexural strength of HFRC were analyzed.

Chitooligosaccharides promote radiosensitivity in colon cancer line SW480.

Aim: To investigate the anti-proliferation and radiosensitization effect of chitooligosaccharides (COS) on human colon cancer cell line SW480.

Methods: SW480 cells were treated with 0, 1.0, 2.

Does the maxillary anterior ratio in Korean adults follow the Golden Proportion?

Purpose: The purpose of this study was to determine the effect of changes in the horizontal plane angle on the mesiodistal width ratios of the maxillary anterior teeth during the acquisition of frontal view photographs, derive these ratios for Korean adults on the basis of the data obtained, and analyze them using the Golden Proportion as a reference.

Materials And Methods: In experiment I, 30 plaster casts were mounted on an articulator and positioned on the angle-measuring device with a center setting of 0°. The device was rotated to 10° in 1° increments in a counterclockwise direction.

Anti-proliferation effect of zoledronic acid on human colon cancer line SW480.

Objective: To investigate the anti-proliferation effect and mechanism of zoledronic acid (ZOL) on human colon cancer line SW480.

Methods: SW480 cells were treated with 0, 12.5, 25, 50, 100 and 200 μmoL/L of ZOL for 48 h, and CCK-8 assay was employed to obtain the survival rate of SW480 cells.

Diagnostic value of interleukin-8 in colorectal cancer: a case-control study and meta-analysis.

Aim: To assess the diagnostic value of serum interleukin-8 (IL-8) in the detection of colorectal cancer (CRC).

Methods: An original study was conducted to explore the potential value of IL-8 in CRC diagnosis. Receiver operating characteristic (ROC) analysis was performed and the area under the curve (AUC) value was calculated.

Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.

1. We tested whether pretreatment of reagents known to induce hypoxia-inducible factor-1 (HIF-1) may confer chemoresistance against cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) to rat C6 glioma cells. We also studied which cytotoxic mechanism(s) of chloroethylnitrosoureas could be neutralized by cobalt preconditioning.

[Effects of H1 blocker and inhaled corticosteroids on asthmatic patients with allergic rhinitis].

Objective: To evaluate the therapeutic effects of H(1) blocker in combination with low dose inhaled corticosteroid on allergic asthma.

Methods: A multi-center, double blind, randomized, placebo control study was conducted in 67 patients with mild to moderate allergic asthma. Patients were randomized to receive either Loratadine 10 mg or placebo twice a day on the basis of inhaled beclomethasone dipropionate (400 microg/d for 14 days, then reduced to 200 microg/d) for 5.