Publications by authors named "Jin-Lan Gong"
Article Synopsis
- Epithelial Mesenchymal Transition (EMT) has been linked to the metastatic potential of tumor cells, and this study investigates Farrerol, a compound derived from a Chinese herb, as a potential treatment to reverse EMT in lung squamous cell carcinoma cells.
- Treatment with Farrerol showed minimal impact on cell viability but significantly altered the expression of EMT markers, leading to a decrease in Slug and Zeb-1 (which promote EMT) and an increase in E-cadherin (an epithelial marker) alongside a decrease in vimentin (a mesenchymal marker).
- Additionally, Farrerol treatment reduced the ability of Calu-1 cells to migrate and invade, suggesting its potential as a therapeutic agent to inhibit metast
In recent years Epithelial Mesenchymal Transition (EMT) has been proposed as a mechanism indispensable to acquisition of metastatic properties by tumor cells. In this study we tested the ability of Ferrerol, a Chinese herb-derived compound to ablate the EMT in human lung squamous cell carcinoma cells. Human lung squamous cell carcinoma cells, Calu-1 were treated with various concentrations of Ferrerol for 24 h to examine its effect on their viability by the MTT assay.
View Article and Find Full Text PDF[Synthesis and characterization of folic acid-conjugated chitosan nanoparticles as a tumor-targeted drug carrier].
Nan Fang Yi Ke Da Xue Xue Bao
December 2008
Objective: To synthesize and characterize paclitaxel (PTX)-loaded folate-conjugated chitosan (FA-CTS/PTX) nanoparticles and evaluate its cytotoxicity in vitro.
Methods: CTS/PTX and FA-CTS/PTX nanoparticles were prepared using reductive amidation and ionic gelation of chitosan with tripolyphosphate anions (TPP). The particle size was determined by laser scattering and the morphology observed using transmission electron microscopy, and the PTX content in the nanoparticles was determined using ultraviolet spectrophotometer at 227 nm.