Publications by authors named "Jin-Lan Cao"
Article Synopsis
- Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths, and this study investigates how aucubin, a natural compound, can inhibit HCC growth and enhance the effects of cisplatin, a common chemotherapy drug.
- Aucubin significantly reduces PD-L1 expression in HCC cells by disrupting the Akt/β-catenin signaling pathway, which helps improve the infiltration of CD8 tumor-infiltrating lymphocytes.
- The findings suggest that combining aucubin with cisplatin could be a promising new therapeutic strategy for treating HCC, as cisplatin typically increases PD-L1 expression, diminishing its effectiveness.
Understanding the mechanisms regulating PD-L1 expression in hepatocellular carcinoma (HCC) is important to improve the response rate to PD-1/PD-L1 blockade therapy. Here, we show that DKK1 expression is positively associated with PD-L1 expression and inversely correlated with CD8 T cell infiltration in human HCC tumor specimens. In a subcutaneous xenograft tumor model, overexpression of DKK1 significantly promotes tumor growth, tumoral PD-L1 expression, but reduces tumoral CD8 T cell infiltration; whereas knockdown of DKK1 has opposite effects.
View Article and Find Full Text PDFBackground: Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion. However, the immune functions of spermine in hepatocellular carcinoma progression remains unknown. In the present study, we aimed to elucidate immunosuppressive role of spermine in hepatocellular carcinoma and to explore the underlying mechanism.
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