Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated transcription factor 4 (ATF4) belongs to the ATF/CREB transcription factor family and primarily participates in the regulation of gene transcription. Our previous study has demonstrated that ATF4 is expressed in sensory neurons.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
April 2015
Objective: To study the effect of thioridazine on the proliferation and apoptosis of human colorectal cancer SW480 cells.
Methods: SW480 cells were treated with different concentrations of thioridazine, and MTT assay was used to evaluate the cell inhibition rate. Hoechst 33342 staining was performed to demonstrate the cell morphology changes.