PM promotes Drp1-mediated mitophagy to induce hepatic stellate cell activation and hepatic fibrosis via regulating miR-411.

Background: Particulate matter≤ 2.5 μm (PM) is a type of environmental agent associated with air pollution, which induces hepatic fibrosis. However, the function and mechanism of PM on hepatic stellate cell (HSC) proliferation and fibrosis remain largely unknown.

PM2.5 induces liver fibrosis via triggering ROS-mediated mitophagy.

Background: The increasing epidemic of fine particulate matter (PM2.5) is a serious threat to human health. It induces the occurrence of liver fibrosis, but its molecular mechanism is not yet clear.

[Comparisons of clinical features of chronic aplastic anemia and myelodysplastic syndrome in children].

Objective: This study compared the differences in clinical features between chronic aplastic anemia (CAA) and myelodysplastic syndrome (MDS) in children in order to provide a basis for the differential diagnosis of the two diseases.

Methods: A retrospective study of 23 cases of CAA and 9 cases of MDS from September 2007 to September 2010 was performed. The clinical data including routine blood test results, reticulocyte counts, serum lactate dehydrogenase level, serum ferritin level, cytological examination of bone marrow, bone marrow CD34+ cell counts, bone marrow chromosome and FISH test results were compared between the CAA and MDS groups.