Publications by authors named "Jin-Huan Ni"
Article Synopsis
- * Out of over 100 tested drugs, sertraline and duloxetine were found to effectively inhibit erdafitinib's metabolism, increasing its levels in the blood and enhancing anti-tumor effects when used in lower doses.
- * The combination of erdafitinib with these drugs not only maintained its effectiveness against tumors but also reduced harmful side effects, suggesting a promising new approach for improving treatment outcomes in cancer therapy.
Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism.
Toxicol Appl Pharmacol
September 2023
Article Synopsis
- The study investigates how genetic variations in the CYP2C19 and CYP3A4 enzymes affect ibuprofen metabolism in a Chinese population, focusing on differences in drug clearance among individuals.
- Researchers identified various enzyme variants and analyzed their effects on ibuprofen metabolism through advanced techniques, revealing that most variants showed altered drug clearance rates compared to the standard (wild type).
- This research is the first to explore these specific genetic influences on ibuprofen metabolism, highlighting the need for more studies on individuals with poor metabolism to improve drug safety and predict potential toxicity.
The objective of this study was to determine the effect of flavonoids on midostaurin disposition considering co-administration and metabolic enzyme gene polymorphism. Enzymatic incubation assays were performed in vitro, while in vivo experiments were conducted in Sprague-Dawley rats. The analytes were determined via UPLC-MS/MS.
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