CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-κB/ROS signaling.

SARS-CoV-2 can encode circular RNAs (circRNAs); however, the potential effects of exogenous SARS-CoV-2 circRNAs on cardiovascular sequelae remain unknown. Three circRNAs derived from the nucleocapsid (N) gene of SARS-CoV-2, namely, circSARS-CV2-Ns, were identified for functional studies. In particular, circSARS-CV2-N1368 was shown to enhance platelet adhesiveness to endothelial cells (ECs) and inhibit EC-dependent vascular relaxation.

[Branchial cleft carcinoma from cleft cyst: report of one case].

Branchial cleft carcinoma is a rare malignancy, there still exist some controversies regarding to the differentiation of branchial cleft carcinomas. This article is aimed to familiarize clinicians with the presentation and treatment of the tumour and explores its origin. A 41-year old man who was seen with a large lesion of branchial cleft carcinoma with a slowly growing mass in the area of the left parotid gland was reported.