Publications by authors named "Jin-Han Yao"
Article Synopsis
- Development of resistance to lapatinib, a treatment for advanced HER2-driven breast cancer, limits its effectiveness over time, necessitating research into its underlying mechanisms.
- The study reveals that while lapatinib successfully suppresses HER2 and inactivates the Akt pathway, it fails to boost p27 levels, a key player in cell death, due to the upregulation of miR-221.
- Targeting this resistance mechanism by using the Src inhibitor dasatinib shows promise in reversing miR-221 effects and restoring p27 levels, providing a potential strategy to enhance lapatinib treatment efficacy.
