Publications by authors named "Jin-Hai Lin"
Article Synopsis
- Cardiovascular diseases are highly prevalent in advanced chronic kidney disease patients, often leading to cardiac dysfunction due to issues like hypertrophy and fibrosis, highlighting the need for new therapies aimed at preserving heart function.
- The study aimed to identify potential treatments for cardiorenal syndrome type 4 (CRS) through a combination of molecular phenotyping and various experimentation methods, including gene expression analysis and different staining techniques.
- The findings revealed that Lobetyolin (LBT) improved cardiac dysfunction in animal models and that its mechanism involves the suppression of Osteopontin (OPN) through JNK signaling, indicating a potential therapeutic pathway for CRS.
HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells.
World J Gastroenterol
December 2014
Aim: To investigate whether hypoxia inducible factor (HIF)-1α modulates vasculogenic mimicry (VM) by upregulating VE-cadherin expression in esophageal squamous cell carcinoma (ESCC).
Methods: Esophageal squamous cancer cell lines Eca109 and TE13 were transfected with plasmids harboring small interfering RNAs targeting HIF-1α or VE-cadherin. The proliferation and invasion of esophageal carcinoma cells were detected by MTT and Transwell migration assays.
Objective: To investigate the effect of hypoxia inducible factor-1α (HIF-1α) on the proliferation, migration and vasculogenic mimicry(VM) in human esophageal squamous cell carcinoma cell line Eca-109 and gastric adenocarcinoma cell line SGC-7901 in vitro.
Methods: The recombinant plasmid pGCsi-shHIF-1α was transfected into Eca-109 and SGC-7901 cells by Lipofectamine(TM) 2000. The inhibitory effect of HIF-1α was measured at protein level by Western blot under normoxia and hypoxia.
Neoadjuvant chemoradiotherapy for resectable esophageal carcinoma: a meta-analysis.
World J Gastroenterol
December 2009
Aim: To compare neoadjuvant chemoradiotherapy and surgery with surgery alone for resectable esophageal carcinoma.
Methods: We used MEDLINE and EMBASE databases to identify eligible studies and manual searches were done to ensure no studies were missed. Trial validity assessment was performed and a trial quality score was assigned.