Publications by authors named "Jin-Gang Ai"
Article Synopsis
- The study focuses on head and neck squamous cell carcinoma (HNSCC) and its metastasis, analyzing data from 702,446 cells to find a new subtype of cancer-associated fibroblasts (CAFs) called SFRP2_CAFs.
- SFRP2_CAFs, derived from smooth muscle cells, show distinct traits that relate to worse survival in HNSCC patients and exhibit interactions with tumor-associated macrophages that promote tumor spread.
- The research highlights NFIX as a crucial transcription factor that influences the behavior of SFRP2_CAFs, using advanced gene regulatory network analysis for validation.
Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of the dysregulated long non-coding RNA (lncRNA) in NPC, we identified a novel lncRNA LINC00669 with an apparent negative correlation to the overall survival from human NPC mRNA expression profiling databases. We further performed RNA pulldown coupled with mass spectrum to find out its target protein, and applied a series of in vitro and in vivo loss-and-gain-of function assays to investigate its oncogenic roles in NPC tumor development and progression.
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