Publications by authors named "Jin-Feng Niu"
Biomaterials
January 2017
Article Synopsis
- Tumor cell lysates (TCL) are used in cancer vaccines, but current strategies haven't delivered strong clinical results, prompting research into better delivery methods like biomaterials.
- A new method involving chitosan nanoparticles with mannose (Man) to specifically target dendritic cells (DCs) was developed, loading these particles with TCL from B16 melanoma cells for testing.
- Results showed that the Man-CTS-TCL nanoparticles enhance DC maturation and improve immune responses, leading to delayed tumor growth and therapeutic effects in melanoma models, indicating their potential as effective cancer vaccines.
