Overexpression of SET and MYND domain-containing protein 2 () is associated with poor prognosis in pediatric B lineage acute lymphoblastic leukemia.

High expression of SET and MYND domain-containing protein 2() has been reported as a poor prognostic factor for various types of cancer. However, there are little published data about clinical significance of in children with ALL. We used real-time polymerase chain reaction (PCR) to detect expression in the bone marrow (BM) samples from 134 newly diagnosed children with ALL.

Low expression of TET2 gene in pediatric acute lymphoblastic leukemia is associated with poor clinical outcome.

Introduction: TET2, a member of the Ten-Eleven translocation gene family, catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine in DNA. Low expression of TET2 has been reported as a prognostic factor for several types of malignancies in adult patients. However, there have been few data on the effect of TET2 mRNA level on the prognosis of children with ALL so far.