Publications by authors named "Jin-Bo Mao"
Int J Biol Macromol
February 2019
Article Synopsis
- Polysaccharide from Phellinus igniarius (PPI) displays immune-regulating effects with minimal toxicity, making it a potential immune adjuvant targeting Toll like receptor 4 (TLR4).
- In experiments with RAW264.7 and peritoneal macrophages, PPI was shown to significantly enhance the mRNA expression and secretion of cytokines through both MyD88 and TRIF pathways, impacting important signaling molecules like IRAK-1 and IRF-3.
- In vivo studies indicated that PPI treatment led to increased OVA-specific antibody production and spleen cell proliferation, confirming its ability to stimulate TLR4 and its role as a promising immune adjuvant.
