Publications by authors named "Jin-Bin Yan"
Comput Biol Chem
October 2024
Article Synopsis
- The integration of AI in smart agriculture improves production and management, aiding sustainable practices.
- Developing new eco-friendly insecticides is challenging, but enhancing drug discovery can speed up research and development.
- The IAPred model, which uses AI to predict insecticidal activity, shows an impressive 86% accuracy and outperforms existing models in identifying effective new insecticides.
Article Synopsis
- - The study examined how uncoupling protein 2 (UCP2) levels changed in rat hearts preserved at low temperatures for 3-12 hours, revealing that UCP2 expression increased as preservation time lengthened.
- - The use of UCP2 inhibitor genipin prevented cardiac dysfunction and ATP production decline but did not affect mitochondrial reactive oxygen species (ROS), while SIRT1 protein levels decreased after hypothermic preservation.
- - Resveratrol, a SIRT1 activator, counteracted the increase in UCP2 and improved cardiac function during preservation, suggesting that regulating UCP2 through the SIRT1 pathway may provide protective effects for preserved hearts.
Mol Med Rep
February 2015
Article Synopsis
- Myocardial dysfunction in sepsis significantly raises the risk of mortality, and the enzyme ALDH2 is essential for heart protection from injury.
- In a study using male rats, LPS treatment led to decreased cardiac output and stroke volume, while ALDH2 activity dropped in a dose-dependent way, although its protein levels stayed the same.
- The specific ALDH2 activator, Alda-1, improved cardiac function and inhibited mitochondrial pore opening caused by LPS, suggesting that boosting ALDH2 activity could protect against LPS-induced heart dysfunction, likely by reducing iNOS expression and MPTP opening.
