A mathematical model of chromosome recombination-induced drug resistance in cancer therapy.

Cytotoxic chemotherapeutics are common treatment methods of many cancers, and patients are often dosed at maximum tolerated dose (MTD), which is trying to eliminate cancer cells as much as possible. However, highly doses chemotherapy may induce unexpected gene mutations or DNA recombinations, which in turn result in unpredictable outcomes and drug resistance. In this study, we focus on the occurrence of DNA recombinations, and present a mathematical model for the influence of genomic disorder due to chemotherapy, and investigate how it may lead to drug resistance.

ParaCells: A GPU Architecture for Cell-Centered Models in Computational Biology.

In computational biology, the hierarchy of biological systems requires the development of flexible and powerful computational tools. Graphics processing unit (GPU) architecture has been a suitable device for parallel computing in simulating multi-cellular systems. However, in modeling complex biological systems, scientists often face two tasks, mathematical formulation and skillful programming.

Propranolol given orally for proliferating infantile haemangiomas: analysis of efficacy and serological changes in vascular endothelial growth factor and endothelial nitric oxide synthase in 35 patients.

We investigated the clinical efficacy of propranolol in treating proliferating infantile haemangiomas, and the serological changes in vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) during treatment. Propranolol was given orally to 35 infants with proliferating haemangiomas in a dose of 1.0-1.

[Electrochemical therapy combined with pingyangmycin injection in the management of high-return flow venous malformation].

Objective: To investigate the clinical effect of electrochemical therapy (ECT) combined with pingyangmycin (PYM) injection for the treatment of high-return flow venous malformation.

Methods: A total of 68 cases of the high-return flow venous malformation were retrospectively analyzed, in which 32 cases received simplely ECT,and 36 cases received ECT combined with PYM injection. The patients were followed up from 6 to 30 months.

Reconstruction for defects of the lower lip after tumor ablation.

Background: The lip carcinoma, which frequently affects the lower lip, is one of the most common cancers of the head and neck region composing 25% to 30% of all oral cancers. The accepted method of therapy for lip cancer is surgical excision and reconstruction. The repair should satisfy 2 fundamental requirements: to achieve appropriate aesthetic quality and to conserve labial function.

On the reducibility of compartmental matrices.

Compartmental analysis is the most important modeling tool in biology and medicine. The perturbation due to a tracer in a biomedical system usually leads to a linear system that can be described by a compartmental matrix. The reducibility of the compartmental matrix has important implications on the system, both analytically and computationally.