Publications by authors named "Jin Zhang"

Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts of iron ions from excess myoglobin in the kidneys, which mediates the overproduction of reactive species with the onset of iron overload via the Fenton reaction, thus inducing ferroptosis and leading to renal dysfunction. Unfortunately, there are no effective treatments for AKI other than supportive care. Herein, we developed a multifunctional nanoplatform (MPD) by covalently bonding melanin nanoparticles (MP NPs) to deferoxamine.

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Background: Numerous species of Ardisia are widely used for their medicinal and ornamental values in China. However, accurately identifying Ardisia species at the molecular level remains a challenge due to the morphological similarities among different species, the complexity of interspecific variation, and the limited availability of genetic markers. In this study, we reported 20 chloroplast genomes of Ardisia species from China and combined them with 8 previously published chloroplast genomes to conduct a comprehensive analysis for phylogenetic relationships and adaptive evolution.

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In recent years, with the continuous deepening of the theory of Wu Yun Liu Qi, the application of Zitan in Shenping Decoction and Shengming Decoction has gradually become widespread. Because Zitan is an imported herbal medicine, it is not commonly used in modern medicine and known as an unusual medicinal material. The unclear original plants may affect the clinical application of this medicine.

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The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis of valuable molecules. We report herein an electrochemical desaturation and β-thiocyanation of cyclic amides under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions and can be applied for late-stage functionalization of bioactive molecules.

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To compare the efficacy and safety of gecacitinib (also known as jaktinib) with hydroxyurea (HU) in treating myelofibrosis (MF) patients. In this multicenter, randomized phase 3 trial (ZGJAK016), intermediate- or high-risk primarily JAK inhibitor naïve MF patients were assigned in a 2:1 ratio to receive either gecacitinib (100 mg twice a day, BID) or HU (500 mg BID). The primary endpoint was the proportion of patients with ≥35% reduction in spleen volume (SVR35) from baseline at week 24.

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Observational studies and meta-analyses have indicated a notable correlation between obesity and vitamin D deficiency, yet the causal relationship between the 2 remains contentious. This study employed a bidirectional Mendelian randomization (MR) analysis to explore the interrelation between obesity-associated body metrics: specifically body mass index (BMI), waist-to-hip ratio (WHR), body fat percentage (BFP), whole-body fat percentage (WHF), and 25-hydroxyvitamin D (25(OH)D) levels. Instrumental variables for BMI, WHR, BFP, whole body fat mass (WFM), and 25(OH)D were carefully selected based on predefined thresholds.

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Temperature stress is one of the major limiting environmental factors that negatively impact global crop yields. is an obligate crassulacean acid metabolism (CAM) plant species, exhibiting much higher water-use efficiency and tolerance to drought and heat stresses than C or C plant species. Previous studies on gene expression responses to low- or high-temperature stress have been focused on C and C plants.

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Accurate quantification of neurotoxic methylmercury (MeHg) in environmental samples is crucial for exploring its formation, behaviors, and risks. Here, we developed and optimized an alkaline digestion-manual purge trap/gas chromatography-cold atomic fluorescence spectrometry (GC-CVAFS) method for the quantification of MeHg in solid matrix samples such as sediments, soils or sedimentary rocks. The alkaline digestion method yielded higher recoveries of MeHg than the acid extraction method.

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The environmental hazards caused by microplastics (MPs) have received widespread attention, but the effects of non-biodegradable and biodegradable MPs of long-term presence on continuously operating sewage treatment bioreactors are not well known. In this study, we investigated the effect of a representative non-biodegradable MP, polyethylene terephthalate (PET), and a biodegradable MP, polylactic acid (PLA), on the nitrogen removal performance of conventional anoxic/aerobic (A/O) process. The NH-N removal efficiencies were suppressed to 91.

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Triple-negative breast cancer (TNBC) represents a highly malignant subtype of breast cancer with limited therapeutic options. In this study, we designed and synthesized a series of 1,4-DHP derivatives by structure-based strategy, 43 was documented to be a potent SIRT3 activator and exhibited profound anti-proliferative activity in BT-549 and MDA-MB-231 cells with low toxicity over normal cells. Additionally, 43 displayed the ability of direct binding to SIRT3 with a K value of 51.

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The ionome represents elemental composition in plant tissues and can be an indicator of nutrient status as well as overall plant performance. Thus, identifying genetic determinants governing elemental uptake and storage is an important goal for breeding and engineering biomass feedstocks with improved performance. In this study, we coupled high-throughput ionome characterization of leaf tissues with high-resolution genome-wide association studies (GWAS) to uncover genetic loci that modulate ionomic composition in leaves of poplar ().

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Replacing the oxygen evolution reaction (OER) with the urea oxidation reaction (UOR) in conjunction with the hydrogen evolution reaction (HER) offers a feasible and environmentally friendly approach for handling urea-rich wastewater and generating energy-saving hydrogen. However, the deactivation and detachment of active sites in powder electrocatalysts reported hitherto present significant challenges to achieving high efficiency and sustainability in energy-saving hydrogen production. Herein, a self-supported bimetallic nickel manganese metal-organic framework (NiMn-MOF) nanosheet and its derived heterostructure composed of NiMn-MOF decorated with ultrafine Pt nanocrystals (Pt/NiMn-MOF) are rationally designed.

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As a well-commercialized and utilized non-Saccharomyces yeast, Torulaspora delbruineckii is gaining increasing relevance in the winemaking industry. However, its ability to produce distinctive aromas in wine has been inconsistently reported in the literature. This study aimed to evaluate the fermentation performance and aroma properties of T.

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The aim of this paper was to assess the differences in clinicopathological characteristics, efficacy and prognosis of neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor2(HER2)-zero and HER2-low hormone receptor (HR)-negative breast cancer (BC) patients, and the impact of HER2-evolution on prognosis before and after NAC. 319 triple negative breast cancer (TNBC) patients who completed NAC and surgery from August 2014 to August 2018 at Tianjin Medical University Cancer Institute and Hospital were included. Clinicopathological features, efficacy of NAC and assessment of prognosis were retrospectively analysed.

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Starch-based hydrogels, characterized by their three-dimensional network structures, are increasingly explored for their biodegradability, low cost, and abundance of modifiable hydroxyl groups. However, a comprehensive understanding of the mechanisms behind the formation and property modulation of these hydrogels has not been systematically described. Drawing from literature of the past decade, this review provides insights into designing multifunctional starch-based hydrogels through various gelation mechanism, crosslinking strategies, and second-network structure.

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BRCA1/BRCA2-containing complex subunit 3 (BRCC3) serves as a deubiquitinating enzyme contributing to multiple inflammation-related disorders. However, the role of BRCC3 in modulating airway inflammation in asthma has not been investigated. This study aimed to examine the role of BRCC3 in airway inflammation using a mouse model of asthma induced by ovalbumin (OVA).

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Spin relaxation of charge carriers in strongly quantum confined perovskite magic-sized clusters has been probed, for the first time, by using polarization-controlled femtosecond transient absorption (fs-TA) spectroscopy. Fs-TA measurements with a circularly polarized pump and probe allowed for the determination of the exciton spin relaxation lifetime (∼1.5 ps) at room temperature based on the dynamics of a photoinduced absorption (PIA) feature peaked at 458 nm.

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Article Synopsis
  • The text discusses how transferring DNA from organelles to the nucleus is crucial for the evolution of eukaryotes, highlighted by a study that identified a specific gene (BSTR) linked to photosynthesis in Populus trichocarpa.
  • BSTR has three exons, with two derived from endophytic sources and one including a large part of a plastid gene related to Rubisco, which is essential for photosynthesis.
  • Overexpressing BSTR in poplar and Arabidopsis plants led to significant increases in plant height (up to 200%) and biomass (up to 200%), demonstrating its potential for enhancing growth under field conditions.
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Objective: College students are considered as a high-risk age group for contracting HPV. HPV vaccines are proved to play a major role in preventing Cervical cancer and related cancers among both men and women. This study aimed to explore influencing factors in intention making-decision of Human papillomavirus vaccine in Chinese college students.

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Article Synopsis
  • * The study focuses on how the protein TIP60 influences cisplatin resistance in SCC cell lines by stabilizing another protein, ΔNp63α, which is linked to treatment failure and recurrence in patients.
  • * Targeting TIP60 may offer a new treatment strategy to enhance the effectiveness of cisplatin and combat resistance in SCC and potentially other epithelial cancers.
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Since 2013, the air quality in China has improved dramatically. However, the regulatory standard as defined in air quality index (AQI) is still the one introduced in 2012. To evaluate the gap between reality and regulation, we study the effectiveness of China's AQI from the perspective of air pollution alert, a system that reflects AQI standard directly.

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