Publications by authors named "Jin Yu Xiao"
Article Synopsis
- Spontaneous cerebral vasomotion is vital for maintaining brain health, and the research presented addresses the challenges in studying it due to limited analytical methods.
- The study introduces a new approach using a baseline smoothing algorithm, enhancing the measurement accuracy of vasodynamics and calcium dynamics in mouse cerebral blood vessels through two-photon microscopy.
- Key findings include a correlation between calcium dynamics and vasomotion, improved measurement techniques that reveal complex vascular movements, and insights into how ischemic stroke affects vasomotion, indicating potential strategies for minimizing stroke-related damage.
Potential nuclear accidents propel serious environmental pollution, and the resultant radionuclide release devastates severely the environment severely and threatens aquatic organism survival. Likewise, ongoing climate change coupled with the gradual increase in global surface temperatures can also adversely impact the aquatic ecosystems. In the present study, we preconditioned zebrafish (Danio rerio) at three different temperatures (18 °C, 26 °C and 34 °C) to investigate the effects of a temperature profile on their radiosensitivity (exposure to 20 Gy of gamma rays) to identify the potential biochemical mechanism responsible for influencing radiosensitivity.
View Article and Find Full Text PDFRadiation-induced gastrointestinal (GI) tract toxicity halts radiotherapy and degrades the prognosis of cancer patients. Physical activity defined as "any bodily movement produced by skeletal muscle that requires energy expenditure" is a beneficial lifestyle modification for health. Here, we investigate whether walking, a low-intensity form of exercise, could alleviate intestinal radiation injury.
View Article and Find Full Text PDFEffect of 17β-oestradiol on T-type calcium channels in the lateral habenula.
J Neuroendocrinol
September 2018
T-type calcium channels (T-channels) are critical for regulating neuronal excitability. Oestrogen alters neuronal excitability by modulating the expression of T-channels. The lateral habenula (LHb), as a link between the limbic system and midbrain structures, expresses T-channels and ERs.
View Article and Find Full Text PDFArticle Synopsis
- Estradiol is a hormone that influences mood, cognition, and sleep, and its effects on lateral habenula (LHb) neurons are not fully understood.
- In a study with ovariectomized female rats, varying doses of estradiol were administered to observe changes in neuronal firing activity and c-Fos expression levels.
- Results showed that estradiol reduced spontaneous firing in LHb neurons and lowered c-Fos mRNA and protein levels, indicating that LHb could be an important area for estradiol's action in the brain.
The Moloney murine leukemia virus (MLV) repressor binding site (RBS) is a major determinant of restricted expression of MLV in undifferentiated mouse embryonic stem (ES) cells and mouse embryonal carcinoma (EC) lines. We show here that the RBS repressed expression when placed outside of its normal MLV genome context in a self-inactivating (SIN) lentiviral vector. In the lentiviral vector genome context, the RBS repressed expression of a modified MLV long terminal repeat (MNDU3) promoter, a simian virus 40 promoter, and three cellular promoters: ubiquitin C, mPGK, and hEF-1a.
View Article and Find Full Text PDF