Diagnostic Performance Using a Combination of MRI Findings for Evaluating Cognitive Decline.

Purpose: We investigated potentially promising imaging findings and their combinations in the evaluation of cognitive decline.

Materials And Methods: This retrospective study included 138 patients with subjective cognitive impairments, who underwent brain MRI. We classified the same group of patients into Alzheimer's disease (AD) and non-AD groups, based on the neuropsychiatric evaluation.

Expression of CD200 in alternative activation of microglia following an excitotoxic lesion in the mouse hippocampus.

CD200 is a glycoprotein that is expressed on the surfaces of neurons and other cells. It interacts with its receptor, CD200R, which is expressed on cells of the myeloid lineage, including microglia. The interaction of CD200 with its receptor plays a significant role in maintaining microglia in a quiescent state; thus, a decrease in CD200 expression in the brain is associated with evidence of microglial activation.

Prioritizing genes associated with prostate cancer development.

Background: The genetic control of prostate cancer development is poorly understood. Large numbers of gene-expression datasets on different aspects of prostate tumorigenesis are available. We used these data to identify and prioritize candidate genes associated with the development of prostate cancer and bone metastases.