Publications by authors named "Jin Young Bae"

Article Synopsis
  • - Studies indicate that astrocytes in the medullary dorsal horn (MDH) are crucial in developing pathological pain, yet their structural changes, specifically in peripheral astrocytic processes (PAP), during neuropathic states are not well understood.
  • - Research using a rat model post-chronic constriction injury revealed significant increases in the number, area, density, and coverage of ezrin-positive PAPs around presynaptic axon terminals and postsynaptic dendrites compared to control rats.
  • - The administration of the mGluR5 antagonist MPEP reversed these structural changes, suggesting that mGluR5 may mediate the reorganization of PAPs and enhance astrocyte-neuron interactions in neuropath
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Importance: Multiple pregnancy is relatively common in many countries and is associated with various pregnancy complications, including preterm birth, low birth weight, and congenital anomalies. In particular, a poorer prognosis has been reported when congenital anomalies overlap with other pregnancy complications in multiple pregnancy compared with singleton pregnancy.

Objective: This study reviews the characteristics of congenital anomalies that occur in multiple gestations as compared with singleton pregnancies.

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: Long and ineffective labor causes hardships for mothers and doctors and increases the rate of cesarean sections and medical comorbidities. Several factors contribute to effective and less painful labor, including maternal age, parity, fetal characteristics, and the medications or procedures that obstetricians use for labor. We aimed to study the factors that affect labor duration and identify those that make labor more effective.

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Introduction: Satellite glial cells (SGCs) that envelop the cell bodies of neurons in sensory ganglia have been shown to both release glutamate, and be activated by glutamate in the context of nociceptive signaling. However, little is known about the subpopulations of SGCs that are activated following nerve injury and whether glutamate mechanisms in the SGCs are involved in the pathologic pain.

Methods: To address this issue, we used light and electron microscopic immunohistochemistry to examine the change in the glutamate levels in the SGCs and the structural relationship between neighboring neurons in the trigeminal ganglion (TG) in a rat model of craniofacial neuropathic pain, CCI-ION.

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Article Synopsis
  • The market growth for ophthalmic medical devices is pushing the need for alternatives to animal testing for eye irritation assessments, leading to a call for novel in vitro testing methods.
  • Researchers evaluated a human corneal model using common contact lens materials (HEMA and PMMA) and various chemicals, following established OECD and GHS guidelines.
  • Results from three certified labs showed the new method demonstrated strong reproducibility and predictive accuracy, suggesting it is suitable for testing eye irritation linked to ophthalmic devices.
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In this study, ionic conductive hydrogels were prepared with 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS). Acrylic acid (AA), acrylamide (AAm), and 2-hydroxyethyl acrylate (HEA) were used as comonomers to complement the adhesion properties and ion conductivity of AMPS hydrogels. Hydrogels were prepared by irradiating a 20 kGy dose of E-beam to the aqueous monomer solution.

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Complications related to the vascular anastomosis of the placental vessels in monochorionic twins are fatal. The clinical syndromes of feto-fetal transfusion include twin anemia polycythemia sequence (TAPS), twin-twin transfusion syndrome, and twin reversed arterial perfusion sequence. We present an extremely rare case of TAPS in a dichorionic diamniotic pregnancy.

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Background: Our objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy.

Methods: We analyzed the national health insurance database, which covers almost the entire Korean population, between 2004 and 2015. The risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma, were analyzed in multivariate logistic regression analysis.

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Microvascular function may be modulated by various anesthetics. Desflurane and propofol anesthesia have different effects on microvascular function. However, there are few reports on the effects of sevoflurane and desflurane on microvascular function during cardiac surgery.

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Article Synopsis
  • Insulin is produced in various brain regions, especially in the hypothalamus, but its specific functions and distribution in the hypothalamus are not fully understood.
  • Researchers discovered that insulin-positive neurons in the mouse hypothalamus are primarily located in the paraventricular nucleus (PVN) and influence growth hormone (GH) production by projecting to the median eminence.
  • Stress appears to inhibit insulin expression in the PVN, which affects GH levels and body growth; manipulating insulin levels in the PVN can either alleviate or worsen growth issues related to stress in mice.
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Aim: The purpose of this study was to evaluate the prognostic factors of patients with stage IIIC1r cervical cancer who underwent concurrent chemoradiotherapy.

Methods: A total of 134 patients treated with chemoradiotherapy for cervical cancer with pelvic and/or paraaortic lymph node metastasis (PALNM) were enrolled in this study. Clinical variables were investigated through review of the patients' medical records.

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Ependymal cells (ECs) are multiciliated neuroepithelial cells that line the ventricles of the brain and the central canal of the spinal cord (SC). How ependymal motile cilia are maintained remains largely unexplored. Here we show that zebrafish embryos deficient in Wnt signaling have defective motile cilia, yet harbor intact basal bodies.

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Background: This study aimed to assess the in-field lymph node (LN) failure rate according to LN size and to investigate effect of LN size on the survival outcome of patients with locally advanced cervical carcinoma treated with concurrent chemoradiotherapy (CCRT).

Methods: A total of 310 patients with locally advanced cervical carcinoma treated with CCRT were enrolled in retrospective study. LN status was evaluated by magnetic resonance imaging.

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Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes.

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Objectives: Chronic obstructive pulmonary disease (COPD) is a fatal disease that shortens one's life expectancy and reduces the quality of life of patients. The current known treatments for COPD can only act to alleviate the symptoms. Recently, stem cells have demonstrated efficacy in various medical areas.

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Article Synopsis
  • Positive emotional experiences, like pleasure, are linked to an increased preference for a certain context, but the mechanisms behind this are not well understood.
  • The study identifies that astrocytic μ-opioid receptors (MOR) in the CA1 region of the hippocampus play a crucial role in driving conditioned place preference (CPP) through long-term potentiation (LTP) triggered by these receptors.
  • The process involves astrocytic glutamate release, which activates presynaptic receptors and strengthens excitatory signals, highlighting the importance of astrocytic connections in forming contextual memories related to positive experiences.
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Ruthenium-quercetin conjugated nanoclusters (Ru-QC NCs) were synthesized via a one-pot reflux reaction. As inhalation of heavy metal ions like cobalt can lead to lung cancer, a fluorescent probe was designed for the determination of Co(II) both in aqueous solutions and living cells. The probe consists of hybrid nanoclusters with an average size of 2 nm that were prepared from ruthenium(II) ions and the flavonoid quercetin.

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Article Synopsis
  • Researchers explored how sensory signals from the urinary bladder connect in the spinal cord, focusing on synapses and neurotransmitters, primarily using advanced microscopy techniques.
  • They found that bladder afferent boutons in the spinal parasympathetic nucleus (SPN) form more connections with postsynaptic dendrites than those in the dorsal horn (DH), indicating a greater potential for synaptic plasticity in the SPN.
  • The study also revealed that in the DH, these boutons receive more inhibitory signals, suggesting that the processing of signals from the urinary bladder differs significantly between these two spinal regions compared to somatosensory information.
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Detailed information about the excitatory and inhibitory synapses on the hypoglossal motoneurons may help understand the neural mechanism for control of the hypoglossal motoneuron excitability and hence the precise and coordinated movements of the tongue during chewing, swallowing and licking. For this, we investigated the distribution of GABA-, glycine (Gly)- and glutamate (Glut)-immunopositive (+) axon terminals on the genioglossal (GG) motoneurons by retrograde tracing, electron microscopic immunohistochemistry, and quantitative analysis. Small GG motoneurons (< 400 μm in cross-sectional area) had fewer primary dendrites, significantly higher nuclear/cytoplasmic ratio, and smaller membrane area covered by synaptic boutons than large GG motoneurons (> 400 μm).

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Purpose: The purpose of this study was to evaluate the effectiveness of intrauterine continuous running suture during cesarean section in pregnant women with placenta previa.

Methods: We enrolled 277 women and medical records were retrospectively reviewed. Pregnant women were grouped according to uterine bleeding control methods as follows: Group A, using intrauterine continuous running suture and Group B (control group) using figure-of-eight suture.

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Article Synopsis
  • Recent research shows that μ-opioid receptors (MOR) are highly expressed in hippocampal astrocytes, but their function had not been previously studied.
  • Activation of astrocytic MOR using a specific agonist, DAMGO, leads to rapid glutamate release, which is absent in MOR-deficient astrocytes.
  • The study suggests that MOR and TREK-1 channels work together to mediate glutamate release, potentially linking astrocytic MOR to the physiological effects of opioids like pain relief and addiction.
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