Hyperbaric Oxygen Treatment for Chronic Insomnia at High Altitude: A Prospective, Randomized, Open-Label, Parallel-Group Trial.

Background: Hyperbaric oxygen (HBO) has been proposed to be effective for treating chronic insomnia at high altitudes.

Methods: Patients suffering from chronic insomnia at high altitude were randomly assigned at a 1:1 ratio to either the hyperbaric oxygen (HBO) treatment group or the control group for a 10-day procedure. The primary outcome was insomnia status, which was assessed via the Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI).

Distribution and migration of pollutant elements during municipal solid waste incineration fly ash melting in a pilot-scale furnace.

The melting/vitrification method is a promising approach for the large-scale, rapid, and harmless disposal of municipal solid waste incineration fly ash (MSWIFA). However, this method inevitably involves challenges related to secondary pollution. A 2 t/d pilot-scale melting furnace was built to investigate the distribution and migration of pollutant components-specifically heavy metals, sulfur, and chloride-within secondary fly ash (SFA), vitrified slag (VS), and ash in the flue gas channel (AFC) during the melting process of MSWIFA.

Current status and influencing factors of pediatric clinical nurses' scientific research ability: a survey.

Background: Enhancing the research abilities of clinical nurses is a pivotal aspect of nursing management. The purpose of this survey is to assess the current state of research abilities among pediatric nurses and to identify the associated influencing factors, thereby providing empirical support for the improvement of research competencies in pediatric nurses.

Methods: Pediatric clinical nurses at a tertiary children's hospital in Nanjing, China from May 1st to 31st, 2024 were included for survey.

Quantum phase transitions in the spin-1/2 XXZ model with staggered γ interaction.

The one-dimensional spin-1/2 XXZ model with the limited case of the staggered Gamma interaction which includes the staggered DM and KSEA interactions is investigated by utilizing the infinite-time evolving block decimation method in the infinite matrix product state representation. It is shown that the staggered DM interaction does not lead to any new phase but expands the XY phase. Contrasted to the DM interaction, the region of the ferromagnetic phase expands into the nematic-ferromagnetic and dimer-Haldane phases with the deconfined quantum phase transition happening in the case of KSEA interaction.

Integration of ATAC-Seq and RNA-Seq Reveals the Role of in Red Light-Induced Fruit Ripening in Strawberry.

Light is an important environmental factor affecting the ripening and quality of strawberry fruit. Previous studies have shown that red light treatment can promote strawberry ripening. Gene expression is closely associated with chromatin openness, and changes in chromatin accessibility are crucial for the binding of transcription factors to downstream regulatory sequences.

Enhanced Acetone-Sensing Performance of a Bilayer Structure Gas Sensor Composed of a ZnO Nanorod Top Layer and a ZnFeO Nanoparticle Decorated ZnO Nanorod Bottom Layer.

In this study, we report a high-performance acetone gas sensor utilizing a bilayer structure composed of a ZnO nanorod top layer and a ZnFeO nanoparticle-decorated ZnO nanorod bottom layer. ZnO nanorods were synthesized via a water-bath method, after which the ZnFeO nanoparticle-decorated ZnO nanorods were prepared using a simple immersion and calcination method. SEM and TEM revealed the porous morphology of the samples and the formation of ZnO-ZnFeO heterojunctions.

Characterization of Feeding Behaviors, Appetite Regulation and Growth Performance of All-Female (+/-;XX Genotype) Common Carp ().

Genome editing has the potential to improve growth and traits of aquatic animals. Assessment of the feeding habits of the genetically modified farmed fish is necessary, as this is closely related to the assessment of their growth performance, which is one of the most important economic traits. Previously, we developed a novel strategy to produce all-female (AF) common carp (+/-;XX genotype) with genome editing, which exhibited a growth advantage compared to the control carp (including control male and female carp).

Microglia programmed cell death in neurodegenerative diseases and CNS injury.

Programmed cell death (PCD) has emerged as a critical regulatory mechanism in the initiation and progression of various pathological conditions. PCD in microglia, including necroptosis, pyroptosis, apoptosis, ferroptosis, and autophagy, occurs in a variety of central nervous system (CNS) diseases. Dysregulation of microglia can lead to excessive tissue damage or neuronal death in CNS injury.

Uniformly aligned Ag NPs/graphene paper for enhanced SERS detection of pesticide residue.

The surface-enhanced Raman scattering (SERS) technique provides a quick and reliable method for detecting pesticide residues. In this study, flexible substrates, composed of orderly arranged silver nanospheres (Ag NPs) films on graphene paper, were fabricated through a simple, low-cost Ag NP self-assembly process at a liquid-liquid interface, followed by transfer of the films onto the graphene paper. The SERS performance of the fabricated substrates was evaluated using a portable Raman spectrometer, with rhodamine 6G (R6G) serving as the probe molecule.

Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression.

It has been established that N-acetyltransferase (murine NAT1 (mNAT1) and human NAT2 (hNAT2)) mediates insulin sensitivity in type 2 diabetes. Here we show that mNAT1 deficiency leads to a decrease in cellular spermidine-a natural polyamine exhibiting health-protective and anti-ageing effects-but understanding of its mechanism is limited. We identify that mNAT1 and hNAT2 modulate a type of post-translational modification involving acetylated spermidine, which we name acetylhypusination, on receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-a key regulator of inflammation and cell death.

Fusobacterium nucleatum promotes PD-L1 expression in cancer cells to evade CD8 T cell killing in breast cancer.

Background: A significant percentage of cancer-related fatalities are caused by breast cancer (BC). Fusobacterium nucleatum (Fn) is a common Gram-negative anaerobic bacterium found in various inflammatory diseases, and there are also reports suggesting its involvement in cancer progression. This study discussed molecular mechanisms of Fn-induced immune escape in BC cells.

Fabrication of Zirconia Ceramic Dental Crowns by Digital Light Processing: Effects of the Process on Physical Properties and Microstructure.

Highly dense zirconia ceramic dental crowns were successfully fabricated by a digital light processing (DLP) additive manufacturing technique. The effects of slurry solid content and exposure density on printing accuracy, curing depth, shrinkage rate, and relative density were evaluated. For the slurry with a solid content of 80 wt%, the curing depth achieved 40 μm with minimal overgrowth under an exposure intensity of 16.

Functions and mechanisms of non-histone protein acetylation in plants.

Lysine acetylation, an evolutionarily conserved post-translational protein modification, is reversibly catalyzed by lysine acetyltransferases and lysine deacetylases. Lysine acetylation, which was first discovered on histones, mainly functions to configure the structure of chromatin and regulate gene transcriptional activity. Over the past decade, with advances in high-resolution mass spectrometry, a vast and growing number of non-histone proteins modified by acetylation in various plant species have been identified.

Association between polyunsaturated fatty acids and depression in women with infertility: a cross-sectional study based on the National Health and Nutrition Examination Survey.

Background: Identifying possible influencing factors is crucial for the depression symptoms of women experiencing infertility. This study aims to explore the association between polyunsaturated fatty acids (PUFAs) and the odds of depression symptoms in women experiencing infertility.

Methods: This is a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES).

Xanthomonas oryzae pv. oryzicola effector Tal10a directly activates rice OsHXK5 expression to facilitate pathogenesis.

Bacterial leaf streak (BLS), caused by Xanthomonas oryzae pv. oryzicola (Xoc), is a major bacterial disease in rice. Transcription activator-like effectors (TALEs) from Xanthomonas can induce host susceptibility (S) genes and facilitate infection.

Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis.

Vagus nerve regulates viral infection and inflammation via the alpha 7 nicotinic acetylcholine receptor (α7 nAChR); however, the role of α7 nAChR in ZIKA virus (ZIKV) infection, which can cause severe neurological diseases such as microcephaly and Guillain-Barré syndrome, remains unknown. Here, we first examined the role of α7 nAChR in ZIKV infection in vitro. A broad effect of α7 nAChR activation was identified in limiting ZIKV infection in multiple cell lines.

Enhanced Chromium (VI) Removal by Micron-Scale Zero-Valent Iron Pretreated with Aluminum Chloride under Aerobic Conditions.

Micron-scale zero-valent iron (ZVI)-based material has been applied for hexavalent chromium (Cr(VI)) decontamination in wastewater treatment and groundwater remediation, but the passivation problem has limited its field application. In this study, we combined aluminum chloride solution with ZVI (pcZVI-AlCl) to enhance Cr(VI) removal behavior under aerobic conditions. The optimal pre-corrosion conditions were found to be 2.

Impacts of COVID-19 on Future Preferences Toward Telework.

This paper presents a study in capturing the impacts of the mandatory pandemic-induced telework practice on workers' perceptions of the benefits, challenges, and difficulties associated with telecommuting and how those might influence their preference for telework in the future. Data was collected through an online survey conducted in South Florida in May 2020. Survey data showed that telework indices (either measured through actual behavior or stated preference) before, during, and after the pandemic were heterogeneous across socio-economic, demographic, and attitudinal segments.

Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup.

Background: Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy-related effects as well as iatrogenic causes. Moreover, stroke can be the first sign of an occult malignancy, termed as malignancy-associated ischemic stroke (MAS). Therefore, timely diagnostic assessment and targeted management of this complex clinical situation are critical.